RESUMO
Movement disorders associated with glial fibrillary acidic protein (GFAP) autoantibodies have rarely been reported as ataxia or tremors. A 32-year-old man with headache and fever, initially diagnosed with viral meningoencephalitis, showed gradual improvement with empirical treatment. Two weeks after the illness, he suddenly developed orofacial, tongue, and neck dyskinesia accompanied by oculomotor abnormalities, which developed into severe generalized choreoballism. Brain magnetic resonance imaging (fluid-attenuated inversion recovery) showed signal hyperintensities in the bilateral globus pallidus interna. The clinical picture suggested an acute inflammatory trigger of secondary autoimmune encephalitis. The autoimmune antibody test was positive for GFAP, with the strongest reactivity in the cerebrospinal fluid (CSF) before treatment and decreased reactivity in serial CSF examinations during immunotherapy. Dyskinesia gradually improved to the extent that it could be controlled with only oral medications. This patient presented with parainfectious GFAP meningoencephalitis with distinctive clinical features and imaging findings.
RESUMO
OBJECTIVES: The aim of this study was to evaluate the correlations of pre-pregnancy maternal BMI(body mass index), and weight gain during pregnancy with Birth weight and Cesarean delivery in full term infants. METHODS: We collected data from 1086 pregnancies without complications, and analysed pre-pregnancy maternal BMI, weight gain during pregnancy, and the incidences of SGA(small-for-gestational age), LGA(large-for-gestational age), cesarean delivery. Chi-square test, T-test, and One way Anova test were performed for stastatical analysis. RESULTS: In pre-pregnancy maternal BMI 26.0kg/m2 group, 0%, 23.6% and 36.4% respectively(p<0.05). In under weight gain during pregnancy group, incidence of SGA was 13.4%, LGA 4.7% and cesarean delivery 15.7% respectively, but in high weight gain group, 4.8%, 19.5% and 21.0% respectively(p<0.05). CONCLUSION: There was significant correlations among pre-pregnancy maternal BMI, weight gain during pregnancy, birth weight and cesarean delivery. From these results, it is considered that antenatal maternal BMI and weight gain during pregnancy are valuable to predict birth weight and cesarean delivery.