RESUMO
Introduction: Hepatopulmonary syndrome [HPS] is known as a chronicliver disease associated with severe pulmonary deoxygenation due tointrapulmonary vascular vasodilation. Although liver transplantationis accepted as a main treatment of HPS, identifying effective drugs forrecovery of HPS can be effective in postponing the transplantation anddecreasing the mortality rate of patients before the transplantation. In thisstudy we briefly reviewed the pathogenesis of HPS and also systematicallyreviewed the current pharmacological treatment of HPS
Method: Pubmed, Scopus, and Google scholar were searched for therelevant English language clinical and experimental articles about themedications used in the treatment of HPS
Results: A total of 38 articles were included in this study which mostlyresulted in decreasing NOS expression, NO production, endothelin-1activation, intrapulmonary angiogenesis and increasing oxygenation
Conclusion: Various drugs have been proposed in treatment of HPS butmore large controlled trial studies, is necessary to determine the exactefficacy of each drugs for HPS recovery