RESUMO
Objectives: One of the major causes of mortality in children is acute gastroenteritis. Vomiting is common in early stages of the disease. The aim of this study was to determine the effect of oral dimenhydrinate [DH] in the control of vomiting in cases of acute gastroenteritis in children
Methods: This double-blind, randomized, clinical trial was conducted in a university-affiliated hospital in a western province of Iran. Two hundred children aged one to 12 years old were randomly assigned to either drug or placebo groups. Children in the drug group received oral DH as four doses of 1 mg/kg every six hours [maximum 200 mg], and children in the placebo group received a placebo drug. The patients variables were compared 24 hours after receiving the first dose and at seven and 14 days after discharge
Results: The mean number of episodes of vomiting was 4.4 +/- 2.5 in the drug group versus 4.4 +/- 2.1 in the placebo group, which was not statistically significant [p<0.050]. The mean number of episodes of diarrhea was 7.4 +/- 3.2 and 10.1 +/- 2.8 in the drug and placebo groups, respectively, [p<0.050]. The duration of diarrhea, side effects, need to revisit, and parent's satisfaction in both groups were also significantly different [p>0.050]
Conclusions: Oral DH in children with acute gastroenteritis does not reduce the number and duration of vomiting. However, our results showed that consumption of DH in acute gastroenteritis patients was effective in reducing the frequency and duration of diarrhea and further investigation into this is warranted
RESUMO
Micropipettes or piston pipettes are used to make most volume measurements in fields such as health, chemistry, biology, pharmacy and genetics. Laboratories must ensure that results obtained using these instruments are reliable; therefore, it is necessary to calibrate micropipettes. Before the start of the calibration process, we must check the precision of measurements. The objective of this work is to compare several methods for calculating the precision of three kinds of micropipettes according to the reference value in ISO 8655-6. The medical tests will not have accurate results, if the volume of the liquid doesn't transfer precisely by micropipettes. Thus, the physician might potentially face problems in the disease diagnosis and its control. In the NCCLS EP5-A2, there is a method to specify and assess the precision of micropipettes by using CV [Coefficient of Variation]. Also there are other methods to estimate and test the CV theory, in the formal statistics texts which could be applied to assess the micropipettes precision. In this research we evaluate the precision of lab micropipettes. Three brands of micropipettes, A, B and C are assigned to measure the distilled water mass by using accurate scale which is accurate up to 10-6 to measure 50-gram weights. The experimental environment is a metrology lab which is approved by Iran Standard and Industrial Researches Organization. A technician sampled at the beginning of the experiment and then after 2 hours, the same technician repeated the sampling. Overall, each micropipette is used to measure 40 times with 10-repeat times for single measurement in 28 work days. Common statistical methods are used to estimate and test the CV. Point estimation of CV for micropipettes A, B and C were 0.50%, 0.64% and 1.56%, respectively. Furthermore, the upper limit of 95% confidence bounds for these three micropipettes using the exact method were 0.53%, 0.69% and 1.65%, respectively. Micropipette A met the ISO 8655-6 standard level, but micropipettes B and C did not. On average, measurement errors in micropipettes B and C were respectively 30% and 3.11 times more than micropipette A. By using the approach of CLS EP5-A2 and confidence interval for CV, precision of the three micropipettes were compared. Only one of them met the ISO 8655-6 standard level, but the others failed
RESUMO
In the diagnosis medical labs, it is very important to evaluate the precision of micropipettes in transferring small amounts of liquids. The medical tests will not result accurately, if the liquid volume doesn't transfer exactly by micropipettes. Thus the doctor faces sort of problems in the disease diagnosis and its control. In the standard CLSI EPS, there is a method to specify and assess the precision of micropipettes, by using CV [coefficients of variation]. Also there are other methods to estimate and test the mention CV theory, in the formal statistic texts which could be used to assess the micropipettes precision. It is the main goal of this research to study the precision of lab micropipettes which are shown by A and B and compared by reference standard value from ISO 8655. In this research we evaluate the precision of the lab micropipettes. Two brands A and B are assigned to measure the distilled water mass by using the accurate scale which is accurate up to 10-6 to measure 50 gram weight. The experimental eenvironment is a metrology lab which is confirmed by Iran Standard and Industrial Researches. A unique technician sampled in the beginning of the work time and after 2 hours repeated the sampling. Totally, each micropipette is used to measure 40 times with 10 times repeat for single measurement in 28 work days. It is used common statistical methods to estimate and test the coefficients of variation theory. Point estimation of CV for micropipettes A and B were 0.50% and 0.64% respectively. Also the 95% confidence upper bounds for these two micropipettes by using likelihood ratio method were 0.53% and 0.64% respectively. The micropipette A confirmed the ISO 8655, but the micropipette B did not. Measurement error in micropipette B was 30% less than micropipette A in average. By using the approach of CLS EP5 and confidence interval for CV, precision of two micropipettes were compared. Only one of them confirmed the ISO 8655, but the other one was failed