RESUMO
BACKGROUND: Philadelphia negative myeloproliferative neoplasms (Ph-MPN) are clonal disorders whose pathogenesis has been elucidated in recent years, creating diagnostic and prognostic algorithms. AIM: To study JAK2, CALR y MPL gene mutations in patients with Ph-MPN. MATERIALS AND METHODS: Descriptive cross-sectional observational study of patients with MPN (2015-2019), reviewing clinical, demographic and laboratory data. JAK2, CALR and MPL gene mutations were analyzed by RT-PCR. Results: We studied 72 patients. Fifty percent had essential thrombocythemia (ET), 26.4% had polycythemia vera (PV) and 23.6% had primary myelofibrosis (PM). Bone marrow biopsy was available in 76.5%. At diagnosis, the mean age was 65.5 years and 61% were symptomatic. A thrombotic event was the most frequent problem in 20% and 25% had splenomegaly. There were statistically significant differences in hematological parameters between the different MPNs. JAK2 V617F mutation was detected in 61.1%. Only 19 JAK2 V617F negative patients were available for CALR and MPL mutation studies, identifying 10 triple negative cases. Kaplan Meier curves showed a median survival of 88 months, being similar in the three MPNs. Causes of death in 20 patients were thrombotic complications in 30%, disease progression in 25%, infection in 20%, other neoplasms in 15% and other causes in 10%. CONCLUSIONS: The presentation and frequency of JAK2 V617F, CALR and MPL mutations in our cohort was similar to those reported in other studies for ET and PM. JAK2 V617F mutation was lower for PV. No significant differences between the three MPNs were observed for overall survival. We could not assess the prognostic value of the mutations.
Assuntos
Humanos , Idoso de 80 Anos ou mais , Policitemia Vera/genética , Trombocitemia Essencial/diagnóstico , Trombocitemia Essencial/genética , Transtornos Mieloproliferativos/genética , Chile , Estudos Transversais , Hospitais Públicos , MutaçãoRESUMO
Resumen Objetivo: Evaluar las percepciones de la enfermedad que se asocian con hábitos de vida saludable en pacientes con enfermedades crónicas en Medellín y municipios aledaños. Método: Estudio prospectivo correlacional basado en la aplicación del cuestionario breve de percepciones de la enfermedad (BIPQ), cuestionario de la salud del paciente (PHQ-9), cuestionario de ansiedad generalizada (GAD-7) y un cuestionario de hábitos de vida saludable. Participaron 51 pacientes con diferentes enfermedades crónicas: migraña, cáncer de seno, diabetes, artritis reumatoide, enfermedad cardiovascular e hipertensión arterial primaria. La evaluación de los hábitos de vida saludable se llevó a cabo tres meses después. Resultados: Se encontró que en promedio los participantes comprenden su enfermedad (M = 8,09, D.T. = 2,48), perciben que sus acciones (M = 7,06, D.T. = 2,79) y el tratamiento (M = 7,89, D.T. = 2,69) la controlan y que esta tiene un carácter crónico (M = 7,49, D.T. = 3,16); que hay correlaciones entre los hábitos de vida saludables (HVS) con la percepción de consecuencias de forma negativa, y la identidad y preocupación emocional de manera positiva (p < 0,05). Además, que una relación lineal entre las consecuencias (Beta = 0,391) y la preocupación emocional por la enfermedad (Beta = 0,311) con los HVS, F (5, 45) = 2,707, p < 0,05. Las proporciones de depresión y ansiedad en la muestra fueron similares a las de la población general. Conclusiones: La percepción de que una enfermedad tiene consecuencias negativas y la preocupación por esta lleva a la implementación de comportamientos saludables.
Abstract Objective: This paper aims to assess illness perceptions associated with healthy lifestyle habits in patients with chronic diseases in Medellin and surrounding municipalities. Method: A prospective correlational study was conducted using a brief illness perceptions questionnaire (BIPQ), a patient's health questionnaire (PHQ-9), a generalized anxiety questionnaire (GAD-7) and a healthy habits questionnaire. 51 patients with different chronic diseases were sampled, illness such as: migraine, breast cancer, diabetes, rheumatoid arthritis, cardiovascular disease and primary arterial hypertension. The assessment of healthy lifestyle habits (HLH) was done three months later. Results: It was found, as a result, that people with chronic diseases understand their illness (M = 8.09, S.D. = 2.48); some of them perceive that their actions (M = 7.06, S.D. = 2.79) and others perceive that their treatment (M = 7.89, S.D. = 2.69) control their diseases and that they have a chronic nature (M = 7.49, S.D. = 3.16). Significant correlations were found between HLH and the perception of consequences in a negative way, and the emotional identity and concern in a positive way (p < 0.05). A linear relationship was found between consequences (Beta = 0.391) and the emotional concern (Beta = 0.311) for the disease with HLH, F (5. 45) = 2.707, p < 0.05. The proportion of depression and anxiety in the sample was similar to general population. Conclusions: The perception that a disease has negative consequences and the concern for it leads to the implementation of healthy behaviors.
Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Estilo de Vida Saudável , Percepção , Doença Crônica , Questionário de Saúde do PacienteRESUMO
Objetivo: Se determinó el diagnóstico oftalmológico de estudiantes de odontología de la Universidad del Valle (Cali, Colombia), y se compararon los hallazgos de la valoración oftalmológica entre un grupo de estudiantes previamente expuestos, y otro de estudiantes no expuestos al uso de la lámpara de fotocurado en la práctica clínica. Métodos: Se aplicó una encuesta por entrevista acerca de posibles patologías, accidentes y variables relacionadas con daño ocular, entre ellas el uso de la lámpara de fotocurado. Adicional a esta, a cada estudiante se le practicó un electroretinograma, una fotografía de fondo de ojo y un examen oftalmológico completo. Resultados: No se encontró una asociación estadísticamente significativa entre el daño ocular y la exposición a la lámpara, pero se observó una tendencia a un mayor porcentaje de estudiantes de noveno semestre que presentaron algún tipo de daño ocular, comparado con los estudiantes de quinto semestre. Conclusiones: Es importante continuar promoviendo y profundizando el conocimiento acerca de medidas de bioseguridad en estudiantes de odontología, docentes, auxiliares y pacientes, así como dar continuidad a trabajos interdisciplinarios como éste, en el cual se trabajó de manera complementaria con oftalmólogos. Se recomienda realizar estudios posteriores a la misma población después de un periodo de tiempo mayor a dos años.(AU)
Objective: We determined the ophthalmic diagnostic of dental students at the University del Valle (Cali, Colombia), andcompared the findings of ophthalmologic evaluation in a group of students previously exposed to the use of the curing light in clinical practice, and other group of students not exposed to it. Methods: It was implemented a survey by interview to report possible diseases, accidents and variables related to ocular pathology, including the use of curing lamp. Additional to this, it was performed an electroretinography, a photograph of eye fundus and a complete ophthalmological examination to each student. Results: It was not found a statistically significant association between injury and exposure to the lamp, but there was a trend towards a higher percentage of ninthsemester students who presented some kind of ocular pathology, compared with students coursing fifth semester. Conclusion: It is important to continue promoting and increasing knowledge about biosafety standards in dental students, dentists, assistants and patients, and give continuity to interdisciplinary work like this, which worked in a complementary manner with ophthalmologists. Further studies are recommended in the same population, after a period longer than two years.(AU)