RESUMO
Objective: To document drugs causing the cutaneous adverse effects and the morphology of these reactions
Methods: This observational study was carried out at Department of Dermatology in a tertiary care hospital for two years to study the cutaneous adverse drug reactions [cADRs] and identify the culprit drug or drugs. A total of 188 patients reporting to dermatology department with cutaneous adverse drug reactions were evaluated. Detailed history, as well as, clinical examination findings were recorded along with investigations wherever required and feasible
Results: The commonest drug reaction was found to be fixed drug eruptions [29.2%] followed by urticaria [20.7%]. The most common class of drugs implicated was NSAIDs in 37.2% of patients followed by antimicrobials in 30.3% of patients. The males in our study outnumbered the females
Conclusion: The clinical patterns and causative agents observed during our study were similar to those observed in other studies except for few variations. When a patient is exposed to new drugs, each time the pharmacokinetic and pharmacodynamic conditions are different. So outcome of drug intake is unpredictable