RESUMO
Background: Infertility is a major issue and a source of social and psychological suffering for many couples. Introduction of assisted reproductive technology (ART) leads to great relief for couples nowadays.Methods: This present observational cross-sectional study was conducted at OBGY Department at Sri Aurobindo Medical College and Post Graduate Institute, Indore and who satisfy the inclusion criteria was studied from 1st April 2021 to 30th September 2022 (18 months). After approval from Institutional ethical committee. Each patient fulfilling the inclusion criteria was included in the study. Informed written consent was taken.Results: The mean age of women in this study was 37.6 years and the most common age group was between 30-50 years. Infertility was mostly unexplained (40%), followed by female factor (33.33%), male factor (16.67%), and combined (10%). 63.33% were singletons, 36.67% twins. Preterm labor (43.33%) was most common. Preeclampsia/eclampsia (33.33%), gestational hypertension, renal failure, gestational diabetes, cardiomyopathy, hepatic failure, HELLP syndrome, and DIC were other complications. 60% were caesarean-sectioned and 40% vaginal delivery. 90.24% of neonates had 5-minute Apgar scores above 7 and 9.76% below 7. 4 stillbirths (9.76%) and 75.68% of live births required NICU admission. 5 neonatal deaths (12.2%) and 21.95% perinatal mortality.Conclusions: There are numerous maternal and perinatal complications linked to ART. Couples should therefore be counselled about these risks while offering them ART as a mode of conception.
RESUMO
Background: Thyroid disorders are among the most common endocrine disorders in the world. Thyroid dysfunction can disrupt a variety of metabolic and physiological processes, including the menstrual cycle. The purpose of this study was to discover a pattern of thyroid dysfunction in women with menstrual disorders.Methods: It is a cross-sectional study that includes 116 women. With reproductive age menstrual disorder. Thyroid dysfunction was tested in women who had menstrual problems. Serum free triiodothyronine (T3), free thyroxine (T4), and thyroid stimulating hormone (TSH) levels were used to assess thyroid function.Results: The mean age of study patients was 25.7�8 years. The most common menstrual disorder was irregular cycle 72.5%, amenorrhea 21.9%, and menorrhagia 5.6%. The majority of the patients were between the ages of 15 and 24 (51.1%), followed by 25-34 (36.1%) and 35-45 (12.9%). The mean free T3 and T4 levels were 2.911.05 pg/ml and 1.420.57 ng/dl, respectively. TSH was 2.0 mIU/L on average (IQR, 1.0-4.0). Thyroid dysfunction was observed in 25.8% of the women (n=60). Subclinical hypothyroidism (14.2%, n=33) was the most common thyroid dysfunction, followed by subclinical hyperthyroidism (6.9%, n=16), overt hyperthyroidism (3%, n=7), and overt hypothyroidism (1.7%, n=4).Conclusions: The study reveals that women with menstrual disorders frequently have thyroid dysfunction, particularly subclinical hypothyroidism. In order to rule out thyroid disorders as potential etiological agents for menstrual disturbances, it may therefore be advantageous to screen patients with menstrual disorders for thyroid function.