RESUMO
Background: Hypertensive disorders are also responsible for perinatal mortality and morbidity. Preeclampsia is a risk factor for stillbirth, IUGR, LBW, Preterm delivery, Respiratory distress syndrome, and admission in the neonatal intensive care unit. Hypertensive disorders account for 8-10% of all preterm births. Aim of the study: This study was conducted to predict gestational hypertension by using serum beta HCG and thereby to follow up the risk patients and to reduce both maternal and perinatal morbidity and mortality. Materials and methods: A prospective study was done to determine the role of βHCG in 100 pregnant women in their second trimester (13-20) weeks, attending Tirunelveli medical college OPD. Duration of study was from March 2018- January 2019. Routine antenatal investigations were done. 5 ml of venous blood sample was collected and tests were carried out. Estimation of serum beta HCG level was done by enzyme-linked fluorescence immunoassay. In the antenatal clinic, the patients were followed up. Results: From the study, it was found, women who have elevated βHCG values in 13-20 weeks were at increased risk of developing PIH. For any test to be used as screening test it should have good sensitivity, specificity, and positive predictive value. In this study, β HCG had Sensitivity – 71.4%, Specificity - 87.1%. Conclusion: While comparing patients with normal BP and pre-eclampsia - βHCG values are elevated in patients with preeclampsia. The sensitivity and specificity of βHCG are very low to be Sheba Rosatee Victor, D Jayalakshmi. Serum β HCG as a predictor and potent marker for pregnancy induced hypertension. IAIM, 2019; 6(3): 38-43. Page 39 useful as a mass screening marker on its own and therefore it should be combined with other serum markers and ultrasound parameters like Doppler study of uterine vessels, which will help in improving its role as a screening tool.
RESUMO
Background: Perinatal outcome is strongly influenced by gestational age and the severity of hypertension as expressed by the need for antihypertensive treatment, irrespective of the underlying syndrome. Severe preeclampsia is associated with different degrees of fetal injury. The main impact on the fetus is under nutrition as a result of uteroplacental vascular insufficiency, which leads to growth retardation. There are short and long-term effects. The immediate impact observed is altered fetal growth resulting in greater fetal liability. Fetal health, as well as its weight, is highly compromised, leading to various degrees of fetal morbidity, and fetal damage may be such as to cause fetal death. Aim of the study: To compare maternal outcomes between normal and PIH mothers in correlation with a serum albumin level. Materials and methods: The study was conducted in Obstetrics and Gynecology OPD of Tirunelveli Medical College. Duration of study was from March 2018 to November 2018. Routine antenatal investigations were done. The maternal outcomes were analyzed between two categories Results: The normal, forceps and LSCS deliveries among the total mothers were 42.4%, 2.0%, and 55.6% respectively. The difference between PIH and normal mothers was not statistically significant (P>0.05). The pre and term among the total mothers were 12.1%, and 87.9% respectively. The difference between the pre and term babies among the PIH and normal was very highly statistically significant (P>0.001). The pre and term among the total mothers were 11.1%, and 88.9% respectively. The difference between the APO and NPO of babies between the PIH and normal mothers was very D Jayalakshmi, Sheba Rosatee Victor. Comparative study on maternal outcomes between normal and PIH mothers with serum albumin level. IAIM, 2019; 6(3): 32-37. Page 33 highly statistically significant (P>0.001). The complicated and normal outcome among the total mothers was 4.0%, and 96.0% respectively. The difference between the complicated and normal outcome between the PIH and normal mothers was very highly statistically significant (P>0.001). Conclusion: Perinatal outcome is strongly influenced by gestational age and the severity of hypertension as expressed by the need for antihypertensive treatment, irrespective of the underlying syndrome. Severe preeclampsia is associated with different degrees of fetal injury. The main impact on the fetus is under nutrition as a result of uteroplacental vascular insufficiency, which leads to growth retardation. There are short and long-term effects. The immediate impact observed is altered fetal growth resulting in greater fetal liability. Fetal health, as well as its weight, is highly compromised, leading to various degrees of fetal morbidity, and fetal damage may be such as to cause fetal death.