A case of squamous cell carcinoma arising from ovarian mature cystic teratoma treated with adjuvant chemoradiation / 대한산부인과학회지

Malignant transformation of mature cystic teratoma is rare and difficult to diagnose preoperatively. Therefore, in the suspected case considering the age, tumor size and imaging findings, it is important to diagnose intraoperatively through a frozen section biopsy. It is clear that aggressive optimal surgical resection should be done in the squamous cell carcinoma arising from mature cystic teratoma. However it is controversy what postoperative adjuvant therapy is optimal in the locally advanced case because of its rarity. We report a case of a 59-year-old woman in the menopause with locally advanced squamous cell carcinoma arising from left ovarian mature cystic teratoma treated with optimal cytoreductive surgery followed by concurrent chemoradiation.

A case of squamous cell carcinoma arising from ovarian mature cystic teratoma treated with adjuvant chemoradiation / 대한산부인과학회지

Malignant transformation of mature cystic teratoma is rare and difficult to diagnose preoperatively. Therefore, in the suspected case considering the age, tumor size and imaging findings, it is important to diagnose intraoperatively through a frozen section biopsy. It is clear that aggressive optimal surgical resection should be done in the squamous cell carcinoma arising from mature cystic teratoma. However it is controversy what postoperative adjuvant therapy is optimal in the locally advanced case because of its rarity. We report a case of a 59-year-old woman in the menopause with locally advanced squamous cell carcinoma arising from left ovarian mature cystic teratoma treated with optimal cytoreductive surgery followed by concurrent chemoradiation.

A case of omental dermoid cyst due to an ovarian autoamputation / 대한산부인과학회지

The dermoid cysts occur most frequently in the ovary and are extremely rare in the greater omentum. We report a case of dermoid cyst of the greater omentum misdiagnosed as right ovarian cyst. She was a 27-year-old woman with an omental dermoid cyst of 6 cm in diameter in the cul-de-sac, and the tumor was resected laparoscopically. The histopathologic diagnosis was dermoid cyst and no evidence of malignancy was noted. The patient had no right ovary and tube. These findings demonstrated possible autoamputation of an ovary with dermoid cyst.

The relationship between serum p53 autoantibodies and prognostic relevance of epithelial ovarian cancer / 대한산부인과학회지

OBJECTIVE: The aim of this study was to determine whether a significant in preoperative serum p53 autoantibodies in epithelial ovarian cancer. METHODS: Serum autoantibodies against the p53 protein (p53 AAb) were analysed with a newly developed enzyme-linked immunosorbent assay (ELISA) based on highly purified and renatured p53. In a hospital -based retrospective study, preoperative sera from 17 patients with epithelial ovarian cancer and 15 patients with benign tumors of the ovaries, 15 healthy women were studies. RESULTS: The prevalence of p53 AAb in patients with epithelial ovarian cancer was 35.3% (6/17). No p53 AAb were found in patients with benign tumors and healthy women. Presence of p53 AAb positively correlated with older age, poor response of chemotherapy. But the differences in the tumor stage, grade, poor progression free survival rate were not statistically significant. CONCLUSIONS: The assessment of preoperative serum p53 AAb seems to have a limited clinical value in the epithelial ovarian cancer.

Two cases of primary serous surface papillary carcinoma of ovary / 대한산부인과학회지

Serous surface papillary carcinoma (SSPC) of ovary is a rare malignant epithelial tumor that is histologically indistinguishable from serous ovarian papillary carcinoma. SSPC is defined as an exophytic papillary tumor originating from the surface epithelium of the ovary. It has been included in the World Health Organization classification of ovarian tumors. SSPC is believed to be a distinct subtype of serous papillary carcinoma of the ovary, and the prognosis is worse than that for serous ovarian papillary carcinoma. Clinically, SSPC usually presents with rapidly progressive intraperitoneal spread at the time of diagnosis. One woman with SSPC and malignant pleural effusion was 56 years old and presented with coughing and dyspnea. The other women was 61 years old and presented with abdominal distension. Their preoperative serum CA 125 level were 982.7 IU/mL and 4387 IU/mL. We experienced two cases of SSPC. In this case report, we present histologic findings, therapeutic modalities of SSPC with a brief review of literatures.