A Case of Pendipronil(R) Poisoning Treated by Hemoperfusion and Methylene Blue / 대한신장학회잡지

Pendipronil(R) overdose is uncommon in Korea. Pendipronil(R) is a selective herbicide used to control most annual grasses and certain broadleaf weeds in field corn, potatoes, rice, etc. and is the substance including pendimethalin and propanil. Pendimethalin is slightly to practically nontoxic by ingestion but may be mildly to moderately irritating to the linings of the mouth, nose, throat, and lungs. Propanil toxicity is evidenced by varying clinical pictures ranging from deep cyanosis in an otherwise alert normal appearing individual to restlessness, dyspnea, extensive hemolytic anemia, methemoglobinemia, sulfhemoglobinemia and serious central nervous system dysfunction. For the treatment of methemoglobinemia, gastric lavage, activated charcoal, methylene blue and exchange transfusion should be used. We experienced a case of acute massive Pendipronil(R) intoxication in 31 years old woman due to voluntary ingestion of 48g of this drug as a suicide attempt. A moderate methemoglobinemia developed, accompanied by drowsy mental status, nausea, vomiting, headache, intensive cyanosis. The patient recovered completely after intravenous methylene blue injection and cellulose coated hemoperfusion charcoal (Adsorba 300C(R)) and conservative treatment.

A Case of Hereditary Hemorrhagic Telangiectasia / 대한간학회지

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant inherited disease characterized by telangiectasias of the skin, mucous membranes, and various organ system. HHT is not unusual in western countries but there were several reported cases of HHT in Korea. Recently we evaluated a 40-year-old postpartum female who had been suffering from recurrent epistaxis and peripartum dyspnea. The patient was diagnosed as a HHT complicated by high output heart failure caused by intrahepatic arteriovenous malformation. This case is reported with a review of relevant literature.