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1.
Chinese journal of integrative medicine ; (12): 415-422, 2018.
Artigo em Inglês | WPRIM | ID: wpr-691385

RESUMO

<p><b>OBJECTIVES</b>To investigate the mechanism of Liuwei Dihuang Pill (, LDP) in treating postmenopausal osteoporosis (PMOP) with Shen (Kidney) yin deficiency.</p><p><b>METHODS</b>In this study, 205 cases of PMOP were divided into the PMOP Shen-yin deficiency group (Group A), PMOP Shen-yang deficiency group (Group B), PMOP without Shen deficiency group (Group C), and control group (Group N). Real-time polymerase chain reaction (RT-PCR) and Western blot techniques were used to observe the effects of LDP treatment on the cardiotrophin-like cytokine factor 1 (CLCF1), ankyrin repeat and SOCS box containing 1 (ASB1), and prokineticin 2 (PROK2) genes and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway.</p><p><b>RESULTS</b>The mRNA (P<0.05) and protein (P<0.01) expression levels of the CLCF1 gene in Group A were significantly lower than the corresponding levels in Group N. After LDP treatment for 3 months, the mRNA expression levels of the CLCF1 gene were obviously up-regulated (P<0.01). After 6-month treatment, the expression levels of CLCF1 mRNA and protein were significantly up-regulated (both P<0.01), and the average bone density of the top femur had significantly increased (P<0.05). In vitro, CLCF1 overexpression resulted in a significant increase in the total protein and phosphorylated protein levels of JAK2 and STAT3.</p><p><b>CONCLUSIONS</b>The CLCF1 gene is an important gene associated with PMOP Shen-yin deficiency and the therapeutic effects of LDP may be mediated by up-regulation of CLCF1 gene expression and activation of the JAK/STAT signaling pathway.</p>


Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Citocinas , Genética , Metabolismo , Medicamentos de Ervas Chinesas , Farmacologia , Usos Terapêuticos , Regulação da Expressão Gênica , Janus Quinases , Metabolismo , Osteoporose Pós-Menopausa , Tratamento Farmacológico , Genética , RNA Mensageiro , Genética , Metabolismo , Fatores de Transcrição STAT , Metabolismo , Transdução de Sinais , Regulação para Cima , Deficiência da Energia Yin , Tratamento Farmacológico , Genética
2.
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 489-491, 2005.
Artigo em Chinês | WPRIM | ID: wpr-234843

RESUMO

<p><b>OBJECTIVE</b>To study the clinical efficacy and adverse reaction of compound Duzhong Jiangu granule (CDJG) on knee joint osteoarthritis (KJO) of Gan-Shen deficiency with stasis in tendon and muscle syndrome.</p><p><b>METHODS</b>The randomized controlled method was adopted in this study, comparative study was conducted in 400 patients in the treated group treated with CDJG and 200 patients in the control group treated with Zhuanggu Guanjie pill (ZGP).</p><p><b>RESULTS</b>The total effective rate in the treated group was 92% and the curative-markedly effective rate was 47%, which were higher than those in the control group respectively. Moreover, CDJG showed superiority in improving symptoms and with shorter initiating time of action as compared with ZGP. However CDJG had the effect more favourable for patients of mild condition.</p><p><b>CONCLUSION</b>CDJG is a kind of effective and safe medicine for treatment of KJO.</p>


Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Diagnóstico Diferencial , Medicamentos de Ervas Chinesas , Usos Terapêuticos , Medicina Tradicional Chinesa , Osteoartrite do Joelho , Tratamento Farmacológico , Fitoterapia
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