Role of voltage-gated sodium channel in tumor metastasis / 国际药学研究杂志

The metastasis is the most important biological characteristic of malignant tumors. Once distant metastasis occurs in the tumor tissue, this usually means that the tumor has entered the advanced stage, so it is difficult to cure with local treatment alone, which is the main cause of death. It has been found that voltage-gated sodium channels (VGSC) are expressed not only in excitable cells but also in many metastatic cells, particularly in certain types of cancer cells and the expression of VGSC is related to cancer migration, invasion and metastasis in vivo. Therefore, this article reviews recent studies on the VGSC in tumor invasion and metastasis.