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Chinese Journal of Pathology ; (12): 184-189, 2007.
Artigo em Chinês | WPRIM | ID: wpr-333935

RESUMO

<p><b>OBJECTIVE</b>To study the influence of beta-amyloid protein (Abeta) and cholesterol on the pathological changes of Alzheimer's disease (AD) and on the expression of nicotinic acetylcholine receptor (nAChR) subunits in the brains of rats.</p><p><b>METHOD</b>The rats were treated by intracerebroventricular injection of Abeta1-42 and fed with a diet containing 5% cholesterol to establish animal model of AD. The pathological changes, learning and memory, and expression of nAChRs of rats were analyzed by Bieoschowsky staining, immunohistochemistry, water-labyrinth, Western blot, and RT-PCR.</p><p><b>RESULTS</b>Abeta intracerebroventricular injection induced Abeta deposition in rat brains and high-cholesterol diet resulted in hypercholesterolemia in the animals. Injection of Abeta caused a reduction of learning and memory of rats and modifications of the expression of nAChRs. Cholesterol enhanced these effects of Abeta on neuropathology and expression of nAChRs.</p><p><b>CONCLUSIONS</b>Abeta can induce marked neuropathological changes, influence the learning and study ability, and modify the expression of nAChRs. Cholesterol can enhance the neurotoxicity of Abeta.</p>


Assuntos
Animais , Feminino , Masculino , Ratos , Doença de Alzheimer , Metabolismo , Patologia , Peptídeos beta-Amiloides , Metabolismo , Córtex Cerebral , Metabolismo , Patologia , Colesterol , Sangue , Sinergismo Farmacológico , Hipercolesterolemia , Sangue , Aprendizagem , Fragmentos de Peptídeos , Metabolismo , RNA Mensageiro , Metabolismo , Distribuição Aleatória , Ratos Wistar , Receptores Nicotínicos , Genética
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