Relationship between endothelin-1 gene polymorphisms and essential hypertension / 第三军医大学学报

Objective To investigate the relationship between Lys198Asn and Taq Ⅰ polymorphisms of endothelin-1 gene and essential hypertension in Chongqing residents.Methods Polymorphisms of Lys198Asn and TaqⅠ were detected in the blood samples from 86 patients with essential hypertension(HT) and 138 normotensive controls(NT) by sequence specific primer-polymerase chain reaction(SSP-PCR) and PCR-restriction fragment length polymorphism(PCR-RFLP).Results In the BMI