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Severe acute pancreatitis (SAP) is an acute abdominal disease characterized by acute onset, serious illness, multiple complications, and high mortality. Surgical interventions have been used throughout the treatment of SAP for a long time, including traditional surgical treatments led by laparotomy and modern surgical treatments led by minimally invasive surgery. Especially in the past 10 years, with the deep understanding of the etiology and pathology of SAP and the increasing complications of traditional surgical treatments, a series of minimally invasive surgical techniques are widely applied in the clinical treatment of SAP, which achieved satisfactory clinical results. Among them, ultrasonic intervention technology plays a key role in the advantages of convenience, minimal invasiveness and strong repeatability. Based on recent literatures at home and abroad, this article reviews the application value of ultrasound interventional techniques in the treatment of SAP.
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Studies have shown that bone marrow mesenchymal stem cells (BMSCs) transplantation can restore the sensory and motor function of patients with ischemic stroke. BMSCs transplantation is a promising therapeutic strategy because of its ability to differentiate into neuron-like cells. This article reviews the inducers that promote BMSCs to differentiate into neuron-like cells in vitro.
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Aneurysmal subarachnoid hemorrhage (aSAH) has high disability and mortality.Cerebral vasospasm is the main cause of ischemic neurological deficit and even cerebral infarction after aSAH.At present,there are many studies on molecular signaling pathways of cerebral vasospasm.This article reviews the signaling pathways of cerebral vasospasm after aSAH.
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Severe acute pancreatitis (SAP) is an acute abdominal disease characterized by acute onset,serious illness,multiple complications,and high mortality.Surgical interventions have been used throughout the treatment of SAP for a long time,including traditional surgical treatments led by laparotomy and modern surgical treatments led by minimally invasive surgery.Especially in the past 10 years,with the deep understanding of the etiology and pathology of SAP and the increasing complications of traditional surgical treatments,a series of minimally invasive surgical techniques are widely applied in the clinical treatment of SAP,which achieved satisfactory clinical results.Among them,ultrasonic intervention technology plays a key role in the advantages of convenience,minimal invasiveness and strong repeatability.Based on recent literatures at home and abroad,this article reviews the application value of ultrasound interventional techniques in the treatment of SAP.
RESUMO
Objective To determine the effects of down-regulating serine/threonine/tyrosine kinase 1 (STYK1) on the proliferation,apoptosis and invasion and on MEK/ERK and PI3K/AKT signaling pathways in human colorectal cancer cell line HCT-15.Methods The expression of STYK1 protein was downregulated by RNA interference technique in HCT-15 cells.Then,the STYK1 protein expression was detected by Western blotting.CCK-8 assay was used to measure the effect of STYK1 down-regulation on the proliferation of the cells,flow cytometry was employed to detect the cell apoptosis,and Transwell chamber assay was adopted for cell invasion ability.The expression levels of p-ERK1/2 and p-AKT were detected by Western blotting.Results Compared with the siRNA NC group,STYK1 down-regulation significantly inhibited the proliferation (P ＜ 0.01) and invasion (P ＜ 0.01),induced cell apoptosis (P ＜ 0.01),and suppressed the expression levels of p-ERK1/2 and p-AKT in the HCT cells transfected with STYK1 siRNA (P ＜0.01).Conclusion STYK1 down-regulation inhibits the proliferation and invasion and induces the apoptosis in colorectal cancer cells,which may be related to its inhibition on the MEK/ERK and PI3K/AKT signaling pathways.