RESUMO
Objective To determine the risk factors of white matter lesions (WML) in non-diabetic patients.Methods Eighty-six non-diabetic patients,admitted to our hospital from October 2010 to October 2011,were included in the study.MRI was performed on these patients for WML,and they were classified into two groups according to the Aharon-Peretz J grading of WML:WML positive group (n=50) and WML negative group (control group,n=36).The clinical data of these patients,including gender,age,history of hypertension,and levels of fasting plasma glucose,2 h postprandial blood glucose,fasting insulin,uric acid,bilirubin,blood lipids and glycosylated hemoglobin,and MR imaging data were collected.Results No statistically significant differences were found in the possible risk factors of WML,except for hypertension history (P=0.00),age (P=0.00),low-density lipoprotein level (P=0.00) and insulin resistance (IR,P=0.00).Multivariate logistic regression analysis indicated that the significant important risk factors of WML included age,hypertension history and IR,and their OR values were 1.1 (95％CI:1.0-1.1,P=0.012),2.2 (95％CI:0.7-7.0,P=0.027) and 3.1 (95％CI:1.5-6.2,P=0.002),respectively.Conclusion Age,hypertension history and IR are the important risk factors for WML in non-diabetic patients.