RESUMO
The apoptosis of nucleus pulposus cells (NPCs) is the main cellular process of intervertebral disc degeneration (IVDD). Our previous studies showed that 17β-estradiol (E
Assuntos
Animais , Ratos , Apoptose , Estradiol/farmacologia , Glicogênio Sintase Quinase 3 beta , Interleucina-1beta , Núcleo Pulposo/metabolismo , Fosfatidilinositol 3-Quinases/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Transdução de Sinais , Serina-Treonina Quinases TORRESUMO
<p><b>OBJECTIVE</b>To evaluate clinical effect of new method of percutaneous Kirschner wire fixation in treating Bennett's fracture.</p><p><b>METHODS</b>Thirteen patients with Bennett's fracture were treated with close reduction and percutaneous Kirschner wire fixation. There were male 8 cases and female 5 cases with an average age of 32 years (range from 20 to 45 years). The mean time from injury to operation was 4.3 days (range from 2 to 7 days). External fixation with plaster slab was applied after operation with an average of 35 days (range from 30 to 41 days). The reduction of articular surface, symptom of ache and function of thumb after operation were evaluated.</p><p><b>RESULTS</b>All the patients were followed up with an average of 6.4 months (range from 4 to 9 months). All fractures united and the articular surfaces were reduced well. Only 1 case has mild pain when activity. The grasp force decreased in all patients.</p><p><b>CONCLUSION</b>Close reduction and percutaneous Kirschner wire fixation has advantage such as simply operation, precisely fixation, high potency ratio. The method especially fits Bennett's fracture with small triangular fragment.</p>