EFFECTS OF CRUDE AND PURIFIED POLYSACCHARIDE FROM GRIFOLA FRONDOSA ON TUMOR GROWTH AND IMMUNEFUNCTION IN MICE / 营养学报

Objective:To compare the anti tumor activity and immune enhancing effect of crude(PGF) and purified (PGF 1) polysaccharide from Grifola frondosa. Methods:S 180 bearing mice were used as animal model. The effects on tumor weight and immune function were investigated. Results:PGF and PGF 1 showed inhibitory activity on S 180 growth. They could also increase weight of immune organs and improved the phagocytic function, DTH response, lymphocyte proliferation, antibody formation in splenic cells and content of serum HC IgM markedly. PGF was better than PGF 1. Conclusion:Both PGF and PGF 1 can inhibit S 180 tumor growth and enhance immune function in S 180 bearing mice.