Effects of Exercise Intervention on Risk Indicators of ECG during Exercise in Males in Their Forties / 中国运动医学杂志

Objective To explore the optimal exercise way of improving the risk indicators of electrocardiogram (ECG) during exercise.Methods Twenty-four healthy male subjects aged between 40 and 49 years old were divided randomly into a control group (n=9),a low amount exercise group of 1200 kcal/wk (n=7) and a high amount exercise group of 2000 kcal/wk (n=8).The intensity of the exercise groups was 65％～ 80％VO2max training in the standard 400 m track for 12 weeks.The accelerometer and polar watch were worn to monitor the exercise process.During the exercise,the exercise amount was controlled using the distance and duration while the intensity was controlled using target heart rate.The subjects took part in the graded exercise test before and after the exercise intervention.Twelve lead electrocardiograms were used to measure the indicators of ST segment depression and corrected QT interval dispersion (QTcd) during the exercise.Results The exercise intervention did not result in significant change in ST segment depression,while the QTcd indicator in both the exercise groups decreased significantly after the intervention (P＜0.05).Moreover,the decrease of QTcd indicator in the low amount exercise group was significantly higher than that of the control group (P＜0.05),while the decrease of QTcd indicator in high volume group was higher than that of the control group (P＜0.01).No significant differences were found in the ST segment depression among the 3 different groups.Conclusion The Twelve-weeks exercise interventions with intensity of 65％ ～ 80％ VO2max and exercise amount of 1200 kcal/wk and 2000 kcal/wk have no effect on the ST segment depression during the exercise.However,they can result in significant decrease in the QTcd of ECG during exercise,reducing the risk of exercise-induced myocardial ischemia.

Sequential therapy of transcatheter arterial embolization combined with percutaneous argon-helium cryoablation for small renal cancers：analysis of clinical effect / 介入放射学杂志

Objective To evaluate the safety and efficacy of transcatheter arterial embolization (TAE) combined with argon-helium cryoablation in treating small renal cancers. Methods During the period from February 2008 to July 2013, a total of 44 patients with small renal cancer were treated with TAE and argon-helium cryoablation at The Medical Imaging Department of Nanjing General Hospital of Nanjing Military Area Command. The renal function was reexamined one month after the treatment. Contrast-enhanced CT or MRI was performed in all patients within 1-3 months after the treatment. By using mRECIST, the therapeutic efficacy was evaluated. All patients were followed up for 12-46 months (mean 28 months). Results A total of 48 lesions in the 44 patients were treated with sequential therapy of TAE and argon-helium cryoablation. Of the 48 lesions, complete remission (CR) was achieved in 38, partial remission (PR) in 6 and stable disease (SD) in 4, the remission rate (CR+PR) was 91.7%. No severe complications occurred in all patients, except one who developed localized hemorrhage during the performance of argon-helium cryoablation, which was improved after symptomatic medication. The mean postoperative hospitalization time was 4 days. Three patients were lost to follow-up, one patient died of esophageal cancer-related complication. The remaining patients were survival during the follow-up period, among them recurrence occurred in five within 13-22 months after the treatment, and the sequential therapy of TAE and argon-helium cryoablation had to be carried out once more. Conclusion For the treatment of small renal cancers, the sequential therapy of TAE combined with argon-helium cryoablation is minimally-invasive, safe and effective, and TAE that is performed before argon-helium cryoablation can reduce the incidence of bleeding occurring in the freezing process. Therefore, this technique should be recommended in clinical practice.

Effects of ePTFE-covered stents versus bare stents on portal hemodynamics in patients of transjugular intrahepatic portosystemic shunts / 中华普通外科杂志

Objective To study the effects of ePTFE-covered stents versus bare stents on portal hemodynamics in portal hypertensive patients receiving TIPS. Methods Sixty patients with portal hypertension underwent TIPS with 8 mm diameter bare stents and ePTFE-covered stent from April 2007 to April 2009. The clinical outcomes were observed after TIPS, and the hemodynamics of potal vein system were studied before and after TIPS and during the follow up using direct portography and color Doppler ultrasound technique. Results TIPS procedures were successful in all patients without major complications. The follow-up of patients with bare stents were (8 ± 4) months and follow-up of ePTFEcovered stents group were (6 ± 4) months. Immediately after the TIPS the portosystemic pressure gradient of the two groups decreased by 60% and 58%, respectively(t =0.79, P >0.05). During the follow-up,portosystemic pressure gradient of bare stents group increased gradually, while that in ePTFE-covered stents group maintained low portosystemic pressure gradient (13.2 ± 1.2) mm Hg vs. (9. 5 ± 2. 9) mm Hg, P =0. 015. The blood velocity and volume of venous return of potal vein system were significantly higher in ePTFE-covered stents group than in bare stents group during the follow-up using color Doppler ultrasound method. The blood velocity and volume of the shunts were significantly higher in covered stents group than in bare stents group after 1 year, (125 ±20) cm/s vs. (88 ±13) cm/s, and (1816 ±380) ml/min vs.(1074 ±239) ml/min, respectively P<0. 01. Conclusions In TIPS patients with ePTFE-covered stents high blood velocity and low portosystemic pressure gradient sustained in contrast with those using bare stents.

Influence of cryosurgery on T cellular immunity in patients with malignancies / 介入放射学杂志

Cryosurgery has already become one of the main means to treat advanced malignancies.Not only can the cryosurgery kill the tumor cells directly, it can make the human body to activate T cellular immunity as well.The purpose of this article is to summarize the achievements in the research related to the influence of cryosurgery on T cellular immunity in patients with malignancies and also to make a prospect of cryosurgery therapy in near future.

Evaluation of targeted argon-helium cryoablation in treating solid tumors / 介入放射学杂志

Argon-helium cryosurgical system has been widely used in the treatment of solid tumors.The basic mechanism of this technique is that the ultra low temperature(below 140℃ ) can act on the diseased tissues, resulting in the formation of ice crystals both inside and outside of the cells and causing the rupture of the cells, which will further produce a series of physical and chemical changes and finally bring about the necrosis of tumor cells.This paper aims to introduce the argon-helium cryosurgical system, focusing on its guiding mode, freezing extent and time, freezing immunity, curative effect and combination of treatments.

Experimental studies of formulated Chinese medicinal herbs as a vascular embolizing agent / 医学研究生学报

Objective: To study the efficacy,safety and relative characteristics of formulated Chinese medicinal herbs as a vascular embolizing agent. Methods: We prepared a mixture as a vascular embolizing agent from several Chinese medicinal herbs,they served as anticarcinogen and/or coagulant according to the Chinese Pharmacopeia.We studied the characteristics of the mixture through embolizing the hepatic artery in eight pigs with it. Results: The mixture was prepared as a suspension.It was easily injected through catheters and showed good histocompatibility and hemo-compatibility without pyrogenetic response and toxicity.The mixture mainly embolized peripheral arteries,maintaining occlusion for 5 weeks and without formation of collateral circulation.We found injuries of normal hepatic tissues as slight hepatocyte hydrops and focal endochyloma necrosis through optical and electronic microscope. Conclusion: This suspended mixture of Chinese medicinal herbs is safe and effective as a potential peripheral embolizing agent.

Study of the tumor-microvessel variation after transcatheter arterial chemoembolization / 医学研究生学报

Biological behavior of tumor has a close relationship with its blood supply from the tumor microvessels.The microvessel density of tumor can affect the progressiveness and prognosis of tumor directly. The application of TACE can kill the tumor cell, destroy its blood vessel, and obstruct its blood supply. The advancement of the tumor micro- vessel variation after transcatheter arterial chemoembolization is reviewed.

Preoperative renal artery infusion chemoembolization for intermediate-and advanced-stage renal carcinoma / 医学研究生学报

Objective:It is difficult to separate intermediate-and advanced-stage renal carcinoma,and in some cases even harder to totally remove it.This study aimed to assess the effect of the renal artery infusion chemoembolization on intermediate-and advanced-stage renal carcinoma before surgery.Methods: Twenty-seven patients with intermediate-or advanced-stage renal carcinoma accepted the Sandwich mode of selective bronchial renal artery embolization 3-7 days before surgery.Then we analyzed both the methods of embolization and surgery after intervention therapy.Results: All the patients were successfully treated by transarterial embolization.During the operation,renal artery pulsatility significantly decreased or even disappeared,with obvious swelling of the surrounding renal tissues but very little bleeding.Conclusion: Preoperative chemoembolization for intermediate-and advanced-stage renal carcinoma can improve surgical conditions,shorten the operation time,decrease bleeding and elevate the success rate.

Endovascular graft exclusion of aortic dissection / 医学研究生学报

Objective:To explore the operative indications, methods, curative effects and clinical prospect of Endovascular Graft Exclusion (EVGE) for descending thoracic aortic dissection (TAD). Methods:Under dynamic supervision of DSA, an EVGE with a stent graft complex of 130 44 mm was performed successfully on a 75 year old man with an aortic dissection (DeBakey ⅢB type). Results:Following the operation, DSA revealed that the intimal tear of the dissection was excluded by the endoluminal stent graft complex and the false lumen disappeared. The postoperative one week and one month, Duplex scan and CTA revealed that the stent graft complex was patent and had an inner diameter of 36 mm, without any migration and torsion. The false lumen of dissection was full of thrombi. The patient was discharged in a week. One month postoperative follow up showed that the patient was recovered to his usual normality. Conclusion:The indications for EVGE are DeBakey ⅢB type aortic dissections with the intimal tear, EVGE is a minus invasive method with a firmly curative effects, its clinical prospect will be very bright.

Advance and application of interventional embolic agents / 医学研究生学报

The development and application of embolic agents is a very important step to vascular embolotherapy and many studies about it have been done at home and abroad.We must know their characteristics very well and choose situable embolic agents and interventional methods.Besides we also need to manufacture even ideal embolic agents.This text reviews the advance and application of many kinds embolic agents.

Effects of Somatostatin-14 and-8 on portal hemodynamics in patients with portal hypertension after intrahepatic portosystemic shunt / 医学研究生学报

Objective:To study the effects of Somatostatin-14 and-8 on portal hemodynamics and plasma levels of the insulin-like growth factor(IGF-1),nitric oxide(NO),endothelin-1(ET-1) and glucagon(GLU) in patients with portal hypertension after transjugular intrahepatic portosystemic shunt(TIPS). Methods:Fourteen portal hypertension patients underwent TIPS,their portal pressures directly measured by the intravenous catheter placed in the portal vein,the hemodynamic changes observed and the plasma levels of IGF-1,NO,ET-1 and GLU determined before and 8 and 24 hours after the infusion of Somatostatin-14 or-8 according to a cross-over design.Results:The average decrease in portal pressure after the intravenous infusion of Somatostatin-14 and-8 was(9.4?1.0) cmH2O and(5.0?1.0) cmH2O,respectively(P0.05) 8 and 24 hours after the infusion.Conclusion:Both Somatostatin-14 and-8 can significantly reduce portal pressure,although the former is more potent than the latter.The underlying mechanism may involve their inhibition of the secretion of GLU,IGF-1 and other hormones as well as their reduction of hepatic metabolism and portal inflow.

Effects of somatostatin and octreotide on portal pressure in portal hypertensive patients undergoing TIPS procedure / 中国普通外科杂志

Objectives The purpose of this study was to compare the effect of somatostatin and octreotide on portal vein pressure in portal hypertensive patients.KG*2MethodsWT5”BZ Portal pressure in 12 patients with portal hypertension after TIPS was measured directly by means of a cathater placed in portal vein after infusion of somatostatin (6 mg/24h) or octreotide(0 6 mg/h). The drugs was infused intravenously and alternatively in each individual patient on day 1 or day 3 after TIPS. Portal pressure was assessed at baseline and at 1、2、4、6、8、12、24、30、36 hours after infusion of each drug.KG*2ResultsKG1The average decrease of portal pressure was 9 4?1 0 cm H 2 O and 5 0?1 0 cm H 2 O respectively after the intravenous infusion of somatostatin or octreotide( P

Study on the vascular imaging and the pathology of breast cancer after neoadjuvant intraarterial chemotherapy / 介入放射学杂志

Objective To observe the vascular imaging the pathological changes in the patients with breast cancer after neoadjuvant intraarterial chemotherapy. Methods Before intraarterial infusion, DSA were performed on 96 patients with breast cancer. Pathological changes were studied after operation. Results The blood supply of breast cancer mainly arises from the lateral thoracic and subscapular arteries. Abnormalities in the vascular architecture of breast cancer include irregular bolus arrangement, contrast staining, pooling of contrast material. Degeneracy and necrosis can be seen in the tumor cells after intraarterial chemotherapy. The stromal edema, infiltration of inflammatory cells and fibroplasia may take place. Conclusions Intraarterial infusion of neoadjuvant chemotherapy is effective in the patients with breast cancer.

The experimental studies of Chinese herbs as a vascular embolization agent for the hepatic arteries / 介入放射学杂志

Objective To study the efficacy,safety and correlative characteristics of Chinese herb as a vascular embolization agent.Methods Vascular embolization agent combined from several kinds of Chinese herb was manufactured and served as anticarcinogen and coagulant according to the chinese Pharmacopeia.The characteristics of the combination embolization agent through embolizing the hepatic arteries in eight pigs were studied. Results The combination agent was a non-homogenous suspension,easily to be injected through 5-F catheter with hyper attenuation under fluoroscopy;simultaneously with good histocompatibility and hemo-compatibility and without feverish response and toxicity.The combination agent mainly embolized the peripheral arteries with maintaining occlusion for 5 weeks and without formation of collateral circulation.Slight injuries of normal hepatic tissues with hepatic cytonecrosis and endochyloma focal necrosis were found through optical and electronic microscopy.Conclusions The Chinese herb combination agent is safe and effective in experimental application with good angioembolic function and a potential peripheral embolization agent.

Combination of TIPSS and azygoportal disconnection for portal hypertension / 介入放射学杂志

Objective To investigate the clinical results of combined TIPSS and azygoportal disconnection for portal hypertension in controlling and preventing esophageal variceal bleeding. Methods From Oct. 1996 to Dec. 2001, 60 patients with portal hypertension were admitted to our department because of variceal bleeding and submitted to the treatment with the combination TIPSS and azygoportal disconnection. According to Child Pugh classification, 11 patients were in class A, 37 in class B, and 12 in class C. 41 patients showed mild ascites and 8 with severe ascites. The mild and severe esophageal varices were proven by upper digestive barium meal. The procedure was divided into two stages; first, TIPSS procedure with the stent of diameter 0.8cm and length 6-7cm was successfully inplanted in all patients, second, all patients underwent azygoportal disconnection two weeks later after TIPSS. Results After the combination TIPSS and azygoportal disconnection, the recent complications included three cases with bleeding at operative fields, one case with infradiaphagmatic abscess and seven with slight encephalopathy. No rebleeding of esophageal varices and death occurred during the treatment. During the follow up of 1-5 years, the rates of shunt occlusion, rebleeding and death were 11.9%, 3.5% and 7.0% respectively. Conclusions The combination TIPSS and azygoportal disconnection is an efficient therapeutic methods for portal hypertension.