Multimodal approach to clinical liver transplantation / 中华外科杂志

<p><b>OBJECTIVE</b>To sum up the clinical experience of liver transplantation.</p><p><b>METHOD</b>A retrospective study was made in 11 patients receiving living donor liver transplantation (LDLT)/and 14 patients having orthotopic liver transplantation (OLT), including one time operation of reduced size liver retransplantation and one time operation of cadaveric liver retransplantation.</p><p><b>RESULTS</b>The voluntary donors were a sister and 10 mothers of recipients. The location of graft included 3 patients of segment II, III, part of IV (not including intermediate hepatic veins), 6 patients of segment II, III, IV (including intermediate hepatic veins), and 2 patients of V, VI, VII, VIII (not including intermediate hepatic veins). The weight range of graft was 270 - 620 g. Twenty-four recipients achieved a long-term survival and retained normal liver function during the follow-up. Only 1 patient died from serious rejection on the 72nd day postoperatively. Ten patients with hepatitis B cirrhosis were treated with lamivudine and anti-HBVIg, and HBV-DNA in serum was negative during the follow-up for 4 approximately 21 months. Copperoxidase, ceruloplasmin and main indexes of liver function became normal in all patients with Wilson's Disease. Postoperative complications included abdominal hemorrhage (2 patients), acute respiratory distress syndrome (5), acute rejection (4), and acute renal function failure (2).</p><p><b>CONCLUSIONS</b>The wise solution to improve the result of liver transplantation and optimize liver resources is the "multimodal approach", by which all kinds of techniques for liver transplantation including CLT, LDLT and RSLT should well developed.</p>

Application of microsurgical technique to hepatic artery reconstruction in liver transplantation / 中华外科杂志

<p><b>OBJECTIVE</b>To explore the value of the microsurgical technique in the reconstruction of hepatic artery.</p><p><b>METHODS</b>From September 2000 to June 2001, we performed liver transplantation for 11 patients including living related liver transplantation (4) and 7 orthotopic liver transplantation (7). Arterial reconstruction was performed under an operating microscope.</p><p><b>RESULTS</b>No patients developed hepatic arterial thrombosis and serious complication, nor death for multiple organ failure.</p><p><b>CONCLUSION</b>Microsurgical technique in reconstruction of the hepatic artery can improve surgical outcome, not only in orthotopic liver transplantation but also in living related liver transplantation.</p>

Relationship between epithelial cadherin and syndecan-1 expressions and invasive characters in hepatocellular carcinoma / 中国普通外科杂志

Objective To study the relationship between expressions of E-cadherin and syndecan-1 in hepatocellular carcinoma(HCC) and the invasive characters of HCC. Methods The expression of E-cadherin and syndecan-1 were observed in 47 HCC cases using immunohischemistry. Results Most HCC cases showed decreased expression of E-cadherin and syndecan-1 (55%, 60%). Their expressions decreased more significantly in HCC larger than 3*!cm in diameter than in HCC less than 3*!cm (P