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Objective To explore the effect of combined gastrointestinal internal and external nutritional support in the treatment of elderly patients with lung cancer.Methods According to the random number table method,86 patients with advanced non-small cell lung cancer(NSCLC) were divided into the control group and observation group,43 cases in each group.The observation group was given nutritional intervention on the basis of treatment in the control group.The 12-month survival rate,median progression time and median survival time were evaluated.The clinical efficacy of the two groups was evaluated.The quality of life before and after treatment was evaluated by the KPS score.Results The 12-month survival rate of the observation group was 39.53％,which was significantly higher than 18.60％ of the control group(x2 =4.56,P =0.03).The median survival time and median survival of the observation group were (7.85 ± 1.27) months,(9.98 ± 1.71) months,respectively,which were significantly higher than (6.07 ±0.98)months,(7.99 ± 1.38)months of the control group(t =7.27,5.93,P =0.00,0.00).The total effective rate of the observation group was 88.37％,which was significantly higher than 55.81％ of the control group (x2 =11.32,P =0.00).The KPS scores of the observation group and the control group after treatment were (73.17 ± 2.75)points,(59.68 ±2.52) points,respectively,which were higher than (52.75 ± 2.02) points,(53.01 ± 1.98) points before treatment,and the KPS scores of the observation group were significantly higher than those of the control group (t =39.24,13.64,P =0.00,0.00).The incidence rate of adverse reaction in the observation group was 48.84％,which in the control group was 55.81％,the difference was not statistically significant (x2 =0.41,P =0.51).The CD4+ cells,CD4+/CD8+ and NK cells in the control group were significantly lower than those before treatment (t =6.14,8.44,7.48,P =0.00,0.00,0.00),which in the observation group were significantly higher than before treatment (t =4.89,5.17,6.33,P =0.00,0.00,0.00),the differences were statistically significant compared with the control group after treatment(t =8.11,4.26,5.88,P =0.00,0.00,0.00).The levels of hemoglobin and albumin in the observation group were significantly higher than those in the control group(t =3.88,6.39,P =0.00,0.00).Conclusion The combination of chemotherapy combined with nutritional intervention in the treatment of locally advanced NSCLC is beneficial to improve the immune function and nutritional status of patients,improve clinical efficacy and survival of patients,better improve their quality of life,and will not increase adverse reactions.
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Objective To explore the clinical curative effect of recombinant human endostatin injection combined with chemotherapy in the treatment of patients with advanced gastric cancer and malignant ascites,and its influence on the quality of life.Methods 62 patients with advanced gastric cancer from July 2012 to July 2015,were randomly divided into observation group (31 cases)and control group (31 cases).The control group was treated with FOLFOX6 chemotherapy,the observation group was given recombinant human endostatin injection on the basis of the treatment of the control group.The two groups were treated for 3 weeks.The curative effect,QOL score,Karnofsky score,the change of serum CEA and CA19 -9 levels and drug adverse reaction incidence before and after treatment were compared in the two groups.Results The RR of the observation group was higher than that of the control group (54.84 vs 29.03%,χ2 =4.239 3,P 0.05).Conclusion The clinical efficacy of recombinant human endostatin injec-tion combined with malignant ascites in the treatment of patients with advanced gastric carcinoma is significant,and can significantly improve the quality of life of patients,has the important research value.
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Objective To explore and evaluate the hemostatic effects of hemocoagulase in elderly surgery bleeding. Methods 150 cases (60~75 years old)admitted to Affiliated Hospital of Chuanbei Medical College for abdominal operation from June 2011 to June 2012 were used as subject. They were divided radomly into hemocoagulase group (50 cases),reptilase group (50 cases)and physiological saline solution group (50 cases). The hemostatic time,hemorrhagic volume,hemorrhagic volume per square unit,and body coagulation parameters in three groups were observed and compared. Results The hemorrhagic volume in hemocoagulase group was (9.2 ±2.7 )g,average hemostatic time was (124.5 ±45.7 )s,and hemorrhagic volume per square unit was (0.3 ±0.1 )g,which were similar with reptilase group,but significantly different with those in physiological saline solution group (P<0.05 ). In hemocoagulase and reptilase groups,the hemorrhagic and hemoagglution time decreased in 30 minutes and 1 day after operation, the differences were statistically significant when compared with physiological saline solution group (P <0.05 ).Conclusion Hemocoagulase has better hemostatic effect on hemorrhagic capillary in elderly surgery.