RESUMO
Cryptococcus neoformans are most common Fungi in central nervous system infection.Incidence of cryptococcal meningitis is on the rise in recent years.The use of antifungal drugs must control majority of cryptoeoccosis,and at least one-third of patients have experienced failure of antifungal therapy,and mortality and disable rate are on the rise.Long-term heavy use of antifungal drugs cause cryptococcus resistance phenomenon,and it is the main cause of treatment failure.Therefore,the study of cryptococcus resistance mechanism is imminent.This review summarizes the research progresses of cryptococcus resistance mechanism in recent years,aiming to provide theoretical guidance for the research of new antifungal drugs and providing basis for individual treatment.