Application of standard operating procedure in equipment operation management in central sterile supply department / 中国医学装备

The standard operating procedure(SOP)for cleaning,disinfection and sterilization equipment was established and implemented by combing the operation procedures of equipment manufacturers for cleaning,disinfection and sterilization,and the equipment manufacturer's instructions for reprocessing the equipment with the technical operating specifications of the Rules for Hospital central sterile supply department(WS310.2-2016).480 pieces of cleaning and disinfection equipment,120 pieces of paper-plastic packaging items and 480 pieces sterilized items under regular monitoring in the hospital before and after the implementation of SOP were compared to obtain data of unqualified articles with respect to cleaning,disinfection,package check and sterilization quality monitoring caused by equipment operation quality.The results showed that after the implementation of SOP,the unqualified rate of cleaning and disinfection,inspection and package,periodic sterilization monitoring related to equipment operation was significantly reduced,the difference was statistically significant(x2=29.427,x2=7.206,x2=24.174;P<0.05).The establishment and application of SOP standardizes the operator's operating behavior and effectively reduces the risk of nosocomial infection caused by equipment operation;it can be used in conjunction with the corresponding scoring standards for professional and technical assessment and continuous quality improvement.

Therapeutic effect of Haobieyangyinruanjianfang on the mouse liver fibrosis caused by schistosomiasis / 中华肝脏病杂志

<p><b>OBJECTIVE</b>To explore therapeutic effect of Haobieyangyinruanjianfang (HBYYRJ) on mouse liver fibrosis by schistosomiasis.</p><p><b>METHODS</b>Mice except for normal control were infected with Japanese schistosome cercarias, after 12 weeks, infected mice were divided into 7 groups: low HBYYRJ group, middle HBYYRJ group, high HBYYRJ group, Fufangbiejiaruangan tablet (FFBJRG) group, colchicine group, 3 months infection group and 6 months infection group. Hepatic fibrosis was found in 3 months infection group. Liver hydroxyproline (Hyp) was determined, matrix metalloproteinase-2 and 9 (MMP-2, MMP-9) were detected with gelatin zymography, serum hyaluronic acid (HA) and precollagen III (PC-III) were detected using RIA.</p><p><b>RESULTS</b>HBYYRJ obviously reduced hepatic fibrosis (probability value less than 0.01). Collagen and HA in 3 months infection group and 6 months infection group were higher than that in normal group (probability value less than 0.01), collagen in high and middle HBYYRJ groups and HA in middle and low HBYYRJ groups were lower than that in 6 months infection group (P less than 0.01, probability value less than 0.05). The expression of MMP-9 and MMP-2 in 3 months infection group and 6 months infection group was higher than that in normal group (probability value less than 0.01), The expression of MMP-9 in three HBYYRJ groups and the expression of MMP-2 in high HBYYRJ group were lower than that in 6 months infection group (probability value less than 0.05).</p><p><b>CONCLUSION</b>HBYYRJ can reduce liver fibrosis caused by schistosomiasis.</p>