Literature Analysis on Administration Sequence and Antibacterial Efficacy in the Combination Use of Am-broxol and Antibacterial Agents / 中国药师

This article reviewed the pharmacokinetic and pharmacodynamic characteristics of ambroxol and the interactions be-tween ambroxol and antibacterial agents. The use order of ambroxol and antiseptic drugs was analyzed and discussed. Ambroxol was a-ble to increase antibiotics concentration in bronchoalveolar lavage fluid (BALF) samples. Besides, ambroxol could destroy the struc-ture of bacterial biofilm(BF) in a dose-dependent manner,and high dose of ambroxol hydrochloride showed good safety. When ambr-oxol and antibacterial agents were in combination use,ambroxol should be administrated before antibacterial agents in order to enhance antibacterial efficacy,since ambroxol could increase the concentration of antibacterial agents in lung and help the antibacterial agents enter the bacterial BF. It was suggested that the label of ambroxol be further improved and revised as follows:①the administration se-quence of ambroxol and antibacterial agents should be stated;②the recommended doses of ambroxol for different indications should al-so be listed in the label;③ the clinical safety and efficacy of high dose of ambroxol should be stated.

Experience about Enhancing the Management of Photophobic Drug Use in Our Hospital / 中国药房

OBJECTIVE:To provide reference for enhancing and standardizing the storage,dispensing and clinical use of the photophobic drug. METHODS:The management system and directory of photophobic drugs were set up in our hospital,and photo-phobic drug were classified into drugs used away from light strictly and drugs used away from light appropriately. Special training for nursing staff and monthly inspection of photophobic drug storage and use by inspection group could help finding problems and doing timely rectification. The number of wards where the problems of clinical photophobic drug use were found were compared be-fore and after management. RESULTS & CONCLUSIONS:After 3-quarter management,the quantity of wards with problems de-creased from 69 to 2,decreasing by 97.1%. The management reinforce of photophobic drug can effectively promote the manage-ment of drugs to be standard and scientific and improve the safety and effectiveness of photophobic drug use.

Analysis and Clinical Intervention of Off-label Drug Use of Thymopentin in Our Hospital / 中国药房

OBJECTIVE:To provide reference for rational drug use in the clinic. METHODS:Medical records of 300 inpa-tients receiving thymopentin were randomly sampled from our hospital during Jul. 2013-Jun. 2014. The indication,solvent dilution, route of medication,dosage,medication course and contraindications were analyzed and evaluated. Comment result fed back and ef-fective clinical invention was done. RESULTS:There was a certain degree of off-label use of thymopentin,and the off-label drug use accounted for 38.33%. Through examination and clinical intervention on clinical rational drug use, remarkable results had been achieved. Thymopentin prescription sampling were analyzed statistically in the third quarter of 2014,and the off-label drug use rate dropped to 14%. CONCLUSIONS:We should strengthen prescription comments and feedback,effective clinical invention should be done,to promote rational use of thymopentin.