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Aim To explore the effect of Liuwei Dihuang decoction ( LWDHD) on the expression of β-catenin, E-cadherin,α-SMA, the pathological changes of renal tissue, and the changes of an epithelial-mesen-chymal transformation ( EMT) in renal tissue of rats with unilateral ureteral obstruction ( UUO ) . Methods Forty-eight SPF grade SD rats were randomly divided into sham group ( Sham), model group ( UUO), Liuwei Dihuang decoction low, medium, and high groups ( LWDHD 3. 375, 6. 75, 13. 5 g · kg
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Objective To explore the difference and clinical significance between cerebral infarction and cerebral hemorrhage in patients with acute cerebral infarction.Methods 41 patients with acute cerebral infarction (cerebral infarction group) and 33 patients with acute cerebral hemorrhage (cerebral hemorrhage group) were selected.All patients were detected for plasma TG,TC,LDL,LP (a),G1U,CRP,UA,RBP and HCY,and compared whether they had significant difference,and to draw the ROC curve to the above related biochemical index level,and to judge the diagnostic value of cerebral infarction and cerebral hemorrhage.Results The level of TG,LDL,UA and RBP in cerebral infarction group was significantly higher than that in cerebral hemorrhage group,and the difference was statistically significant (t=2.0～ 4.36,all P＜0.05).The level of GLU and CRP in the cerebral infarction group was significantly lower than that in the cerebral hemorrhage group,and the difference was statistically significant (t=2.99,2.87,all P＜0.05).There was no significant difference in plasma TC,LP(a) and HCY levels between cerebral infarction group and cerebral hemorrhage group (t =0.95～1.85,all P＞0.05).The area under the ROC curve of subjects with TG,LDL,UA,GLU,CRP and RBP level AUC was 0.648,0.652,0.783,0.728,0.749 and 0.649 respectively and there was statistical significance in the judgment of cerebral infarction (all P＜0.05).The area under the ROC curve of plasma UA,GLU and CRP in patients with intracerebral hemorrhage AUC was 0.706,0.804 and 0.837 respectively,and there was statistical significance in the judgment of cerebral hemorrhage.Conclusion There were signifi cant differences between cerebral infarction and cerebral hemorrhage in related biochemical indexes,which could be used to differentiate cerebral infarction from cerebral hemorrhage.
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Objective To explore the changes of preoperative blood parameters of ovarian cancer patients.Methods The pop ulation that we studied consisted of 29 patients with ovarian cancer and 30 cases of ovarian benign tumors controls,calculated neutrophils and lymphocytes ratio (NLR),lymphocytes and monocytes ratio (LMR),red blood cell distribution width (RDW),platelet and lymphocyte ratio (PLR) and CA-125 levels.According to the clinical stage of ovarian cancer patients,the differences of NLR,LMR,RDW,PLR and CA 125 were analyzed in different stages.The above parameters were used to draw the ROC curve for ovarian cancer.Results The average NLR,LMR,RDW,PLR and CA 125 value in experimental and controlled were 2.49±1.04 vs 1.46±0.45,4.48±1.56 vs 6.67±1.87,175.35±62.86 vs 127.11±41.99,(12.98± 0.98)％ vs (12.48±0.76)％ and (355.9±369.73)U/ml vs (12.87±6.91)U/ml respectively.The differences were statistically significant (t =4.979.4.879.3.477,2.188,5.082,all P＜0.05).(Ⅰ + Ⅱ) stage and (Ⅲ +Ⅳ) stage of ovarian cancer patients m the above mentioned parameters mean differences were statistically significant (t=3.379,2.740,3.855,2.940,3.226,all P＜0.05).The area under ROC of NLR,LMR,RDW,PLR and CA 125 value in diagnosing ovarian cancer were 0.874,0.823,0.749,0.680 and 0.905 respectively.Conclusion Some blood routine parameters can be used to identify benign and malignant ovarian tumors,and have positive significance in the clinical staging of ovarian cancer.