Human Skin Safety Test of Green Tea Cell Extracts in Condition of Allergic Contact Dermatitis

Various kinds of positive effects of green tea extracts had been studied for long time which included anti-inflammation, anti-aging, and cardiometabolic effects. Although topical steroid and non-steroidal calcineurin inhibitors may control clinical symptoms of allergic contact dermatitis, some of patients also present allergic reaction to these topical agents. Therefore, we have tried green tea extracts for managing this skin disorder with expectation of anti-inflammatory effect without potential side effects including skin irritation and toxic responses. The toxicity test of green tea extract also did not show any sign of irritation in the skin throughout the test period. Moderate severity of allergic contact dermatitis presented satisfactory clinical outcome at second week follow-up which was final visit of outpatient. This result mean that green tea extract has a positive effect for managing allergic contact dermatitis but its potency and efficacy seem to be so not strong enough to control moderate severity allergy skin lesion. In this pilot study, we were able to conclude that green tea cell extracts might be applied for potential anti-inflammatory soaking without skin toxicity.

Treatment of Atopic Dermatitis Associated with Malassezia sympodialis by Green Tea Extracts Bath Therapy: A Pilot Study

Multiple treatment modalities, including topical and systemic corticosteroid and phototherapy, have been used in treatment of patients with atopic dermatitis. However, long-term corticosteroid therapy may have various adverse effects. The purpose of this study was to investigate the therapeutic efficacy and safety of bath therapy using green tea extracts for treatment of patients with atopic dermatitis. A total of four patients with atopic dermatitis were enrolled in this study. A Malassezia multiplex detection kit was used in performance of multiplex PCR on clinical isolates, which confirmed Malassezia sympodialis. Subjects underwent treatment with bath therapy using green tea extracts three times per wk for a period of 4 wk. Assessment using the scoring atopic dermatitis (SCORAD) index, the visual analogue scale for pruritus, and transepidermal water loss was performed weekly. Laboratory tests were performed before and after treatment. All patients showed marked improvement on the mean SCORAD and visual analogue scale, and a significant decrease in the mean values of serum eosinophil counts was observed after treatment. Bath therapy with green tea extract is an effective, safe, and nonsteroidal therapy for treatment of patients with atopic dermatitis associated with Malassezia sympodialis.

Collection Method and Specificity Analysis of Korean HLA Anti-Body Sera

In order to obtain a reliable test result of the HLA detection of major histocompatibility antigen, it is very significant to get complete result by using excellent anti-sera. so far no standard sera for HLA type has been seen in Korean people. Because we have been unable to find Korean specific antigen in Korea, we have performed screening test on the 150 pregenancy women in order to find an excellent Korean anti-HLA anti-body sera. To get panel lympocyte reaction, 20 healthy Korean and 34 healthy japanese who were well aware of HLA type were given microlymphocyte toxicity test of Thrasaki method. The result showed the the 10percent of the 150 persons had anti HLA sera. Of 10 percent, 2 persons indicated having P 50. it is estimated that there are unknown A, B locus blank and antigen still seisted among many Koreans and we are ging to screen about 2,000 more persons in the future.

Statistical Study of High Rish Infant

An accurate diagnosis and early treatment for high risk pregnancy can certainly lessen neurological sequence, psycho-motor development and disturbance in mental development according to a modern medicine. Also it helps children develop and adujust to a normal life. The authors studied 230 cases of high risk infants admitted in the nursery of Taegu Presbyterian Medical Cender during the period from January, 1978 to June 1979, and following results have been obtained by closely observing the factor, frequency and infection of these cases: 1. The most frqeuent factor of high risk infant and pregnancy was 108 cases of low birth weight which indicated 46.9% of the 230 cases, and 22 cases of C-Section which indicated 9.5%. 2. The relation of mortality rate, gastational age and low bitrh weight indicated the lowest mortality rate in the gestational age between 37 weeks and 43 weeks and weight between 2,500 gm and 4,000 gm. The highest mortality rate was 71 percent in the gestationa lage of 30 weeks and weight under 1,500gm. 3. The frequency of low birth weight(prematured) babies and ages of their mothers indicated that there was none under the age of 16 and 4 cases above the age of 40. 4. Congenital Anomaly: Seven cases of 230 cases. 5. Bacterial study performed within 23 hours of 37 Premature of Membrane indicated that 17 cases were Hemolytic staphylo-epidermis(48.6%) observed from their skin and 4-cases were L-hemolytic streptococcus(11.1%) observed from their throat.