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1.
Acta Pharmaceutica Sinica ; (12): 1000-1003, 2006.
Artigo em Chinês | WPRIM | ID: wpr-294899

RESUMO

<p><b>AIM</b>To seek for new components as BACE inhibitors from Aloe arborescens.</p><p><b>METHODS</b>The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.</p><p><b>RESULTS</b>Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.</p><p><b>CONCLUSION</b>Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.</p>


Assuntos
Humanos , Aloe , Química , Secretases da Proteína Precursora do Amiloide , Metabolismo , Antraquinonas , Química , Farmacologia , Ácido Aspártico Endopeptidases , Metabolismo , Cromonas , Química , Farmacologia , Inibidores Enzimáticos , Química , Farmacologia , Glucosídeos , Química , Farmacologia , Conformação Molecular , Estrutura Molecular , Componentes Aéreos da Planta , Química , Extratos Vegetais , Química , Farmacologia , Plantas Medicinais , Química , Pironas , Química , Farmacologia
2.
China Journal of Chinese Materia Medica ; (24): 44-46, 2005.
Artigo em Chinês | WPRIM | ID: wpr-276647

RESUMO

<p><b>OBJECTIVE</b>To study the chemical constituents from n-butanol extracts of Periploca calophylla.</p><p><b>METHOD</b>The constituents were isolated and purified by chromatographic technology and their structures were elucidated on the basis of physicochemical property and spectroscopic methods.</p><p><b>RESULT</b>Eight glycosides were isolated and identified as periplocin (I), kaempferol 3-alpha-D-arabinoside (II), kaempferol 3-O-beta-D-glucoside (III), 3',4',5,7-tetrahydroxyflavanone-2(S)-3'-O-beta-D-glucopyranoside (IV), (+)-syringaresinol-4'-O-beta-D-monoglucoside (V), 1-sinapoylglucoside (VI), erigeside C (VII), 2,6-dimethoxy-4-hydroxyphenol 1-O-beta-D-glucoside (VIII).</p><p><b>CONCLUSION</b>All the compounds were isolated for the first time from this plant.</p>


Assuntos
Arabinose , Química , Butanóis , Química , Glicosídeos , Química , Quempferóis , Química , Periploca , Química , Plantas Medicinais , Química , Rizoma , Química , Saponinas , Química
3.
Acta Pharmaceutica Sinica ; (12): 1127-1130, 2005.
Artigo em Chinês | WPRIM | ID: wpr-253518

RESUMO

<p><b>AIM</b>To study chemical constituents of the aerial parts of Rhamnus crenatus sieb. et zucc.</p><p><b>METHODS</b>The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.</p><p><b>RESULTS</b>Five compounds were isolated and their structures were identified as crenatoside (1), torachrysone (2), emodin (3), emodin-1-O-beta-D-glucopyranoside (4) and beta-sitosterol (5) respectively.</p><p><b>CONCLUSION</b>Compound 1 is a new compound and the others were isolated from Rhamnus crenatus for the first time.</p>


Assuntos
Ácidos Cafeicos , Química , Emodina , Química , Glucosídeos , Química , Conformação Molecular , Estrutura Molecular , Componentes Aéreos da Planta , Química , Plantas Medicinais , Química , Rhamnus , Química , Sitosteroides , Química
4.
China Journal of Chinese Materia Medica ; (24): 528-531, 2004.
Artigo em Chinês | WPRIM | ID: wpr-256316

RESUMO

<p><b>OBJECTIVE</b>To study the chemical constituents from Hemiphragma heterophyllum.</p><p><b>METHOD</b>The constituents were isolated and purified by chromatographic technology and their structures were elucidated by physico-chemical evidence and spectral data.</p><p><b>RESULT</b>Eight compounds were isolated and identified as hemiphroside C (I), plantainoside E (II), hemiphroside A (III), acetoside (IV), globularin (V), 10-(Z)-cinnamoyl-catapol (VI), iso-scrophularioside (VII), cinnamic acid (VIII).</p><p><b>CONCLUSION</b>Compound I was a new phenylethanoid glucoside and compounds II and VI were isolated for the first time from this plant.</p>


Assuntos
Ácidos Cumáricos , Química , Dissacarídeos , Química , Conformação Molecular , Estrutura Molecular , Plantas Medicinais , Química , Scrophulariaceae , Química
5.
China Journal of Chinese Materia Medica ; (24): 535-537, 2004.
Artigo em Chinês | WPRIM | ID: wpr-256314

RESUMO

<p><b>OBJECTIVE</b>To investigate the chemical constituents of Securinega suffruticosa.</p><p><b>METHOD</b>It was isolated and purified by silica gel chromatography. Their structures were elucidated by means of spectral analysis.</p><p><b>RESULT</b>Four compounds were isolated and identified as ent-phyllanthidine (1), virosecurinine (2), 14,15-dihydrovirosecurinine (3) and viroallosecurinine (4).</p><p><b>CONCLUSION</b>All of four compounds were isolated from S. suffruticosa for the first time and were the enantiomers isolated from this plant before.</p>


Assuntos
Alcaloides , Química , Azepinas , Química , Euphorbiaceae , Química , Compostos Heterocíclicos de 4 ou mais Anéis , Química , Lactonas , Química , Estrutura Molecular , Piperidinas , Química , Folhas de Planta , Química , Plantas Medicinais , Química
6.
Acta Pharmaceutica Sinica ; (12): 633-635, 2002.
Artigo em Chinês | WPRIM | ID: wpr-312065

RESUMO

<p><b>AIM</b>To investigate the chemical components of Boswellia carterii.</p><p><b>METHODS</b>Chromatographic technologies were used for separation and purification, while spectral analysis was used for structure elucidation.</p><p><b>RESULTS</b>Six compounds were isolated and their structures were identified as acetyl-alpha-boswellic acid (1), acetyl-beta-boswellic acid (2), lup-20(29)-ene-3 alpha-acetoxy-24-oic acid (3), alpha-boswellic acid (4), beta-boswellic acid (5) and acetyl-11-keto-beta-boswellic acid (6).</p><p><b>CONCLUSION</b>Compound 3 is a new constituent.</p>


Assuntos
Humanos , Antineoplásicos Fitogênicos , Farmacologia , Boswellia , Química , Divisão Celular , Células HL-60 , Estrutura Molecular , Plantas Medicinais , Química , Triterpenos , Química , Farmacologia
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