Structural Differences in Series Scores of Hamilton Anxiety Scale in Parkinson's Disease Patients / 中国康复理论与实践

Objective:To explore the structural differences in series scores of Hamilton Anxiety Scale (HAMA) in Parkinson's disease patients with anxiety. Methods:From January, 2016 to December, 2017, 180 inpatients with Parkinson's disease in Center for Neurodegenerative Disease, Beijing Tiantan Hospital were reviewed. Their age, gender, course of disease were recorded, and were assessed with HAMA, Hamilton Depression Scale (HAMD), unified Parkinson's Disease Rating Scale III (UPDRSIII)，Hoehn-Yahr stage and Mini-Mental State Examination (MMSE). They were divided into non-anxiety group, possible anxiety group, anxiety group and very anxiety group according to the scores of HAMA. The demographics, clinical data and series scores of HAMA were compared among these groups. The correlation between HAMA and HAMD were anlyzed. Results:The course of disease, UPDRSIII scores and the most improvement ratio by drug increased with the severities of anxiety (F > 4.951, P < 0.001), as well as the series scores of HAMA (F > 188.241, P < 0.001); however, the proportion of psychogenic anxiety score increased with the severities of anxiety. The scores of HAMA correlated with the scores of HAMD (r = 0.665, P < 0.05). Conclusion:The more serious the anxiety is, the more psychogenic are in Parkinson's disease patients.

Structural Differences of Depression for Patients with Parkinson's Disease Using Hamilton Depression Scale / 中国康复理论与实践

Objective:To explore the structural differences and the trend in series scores of Hamilton Depression Scale (HAMD) in patients with Parkinson's disease (PD). Methods:From June, 2017 to March, 2018, 168 PD patients from Beijing Tiantan Hospital were reviewed. Their genders, ages, courses of disease, Hamilton Depression Scale (HAMD) scores, unified Parkinson's disease rating scale III (UPDRS III) scores，Hoehn-Yahr stage and Mini-Mental State Examination (MMSE) scores, the most improvement ratios by PD drug and other clinical data were collected. The patients were divided into non-depression group (n = 61), mild depression group (n = 68) and moderate depression group (n = 39) according to the HAMD scores. The series scores of HAMD among the groups were compared. Results:The factor scores all increased with depression exacerbating (F > 10.546, P < 0.001), except day and night change in the mild depression group, while the proportion of anxiety/somatization score decreased, and the proportion of cognitive disorder and retardant scores increased. Conclusion:The depression structure changes in PD patients with depression exacerbating, which means decrease of anxiety/somatization and increase of cognitive disorder and retardant.