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Objective To assess the feasibility and safety of transradial puncture route for digital subtraction angiography (DSA)in young patients with ischemic cerebrovascular disease. Methods One hundred young patients with cerebrovascular disease who underwent whole brain angiography at the Department of Neurology,the 81 st Hospital of PLA were enrolled. They were divided into either a radial group (n =50)or a femoral group (n = 50)using a computer random number method. The time of puncture,success rate of puncture,success rate of selective angiography,exposure time,and incidence of complications were compared and analyzed. Results (1)The puncture time of the radial group was significantly longer than that of the femoral group,they were 3. 00 ± 0. 50 min and 1. 50 ± 0. 25 min respectively. There was significant difference (t = 18. 97,P 0. 05). (2)The incidence of complications of the radial group (4%,n = 2)was significantly 1ower than that of the femoral group (18%,n = 9 ). There was significant difference between the two groups (χ2 = 5. 01,P < 0. 05 ). Conclusion Transradial route puncture for whole brain DSA in young patients with cerebrovascular disease is safely and feasible.
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Objective To investigate the risk factors for cognitive impairment after ischemic stroke.Metbods The Mini-Mental State Examination (MMSE) scale was used to screen the patients with cognitive impairment within 3 days after the onset of ischemic stroke.The patients were divided into either a cognitive impairment group or a non-cognitive impairment group according to the MMSE scores.Demographics,vascular risk factors,and clinical data were compared in both groups.The independent risks factor for cognitive impairment after ischemic stroke were analyzed by using multivariate logistic regression analysis.Results A total of 202 patients with ischemic stroke were included in the study,in which 48 (23.8％) were in the cognitive impairment group.The proportions of age (66 ± 6 years vs.57 ± 5 years; t =2.231,P =0.038),previous diabetes (39.6％ vs. 18.2％ ; x2 =9.388,P =0.003 ),history of stroke or transient ischemic attack (39.6％ vs.20.8％;x2 =6.856,P=0.007),and the baseline National Institutes of Health Scale scores (11.8 ±2.4 vs,8.1 ± 1.9; t =2.046,P =0.043),as well as serum homocysteine (29.2± 7.8 μmol/L vs.19.9 ±6.5 μmol/L; t =2.781,P =0.008),uric acid (401.5 ± 51.1 μmol/L vs.312.4 ± 60.7 μmol/L; t =3.042,P=0.003),and C-reactive protein (18.4 ±5.2 μmol/L vs.11.3±4.2 μmol/L;t=2.903,P=0.004)levels in the cognitive impairment group were significantly higher than those in the non-cognitive impairment group.Multivariate logistic regression analysis showed that tha age (odds ratio [OR] 1.812,95％ confidence interval [CI] 1.138 -3.205; P =0.039),history of diabetes (OR 2.520,95％ CI 1.854 -4.111; P =0.025),history of stroke or transient ischemic attack (OR 4.232,95％ CI 1.905 - 8.582; P =0.014),as well as the increased levels of serum homocysteine (OR 3.618,95％ CI 2.061 -6.312; P =0.018),uric acid (OR 2.179,95％ CI 1.654 - 3.836; P =0.031),and C-reactive protein (OR 2.716,95％ CI 1.507 - 5.552; P =0.022)were the independent risk factors for cognitive impairment after ischemic stroke.Conclusions The incidence of cognitive impairment after the onset of ischemic stroke was higher.The age and the history of stroke or transient ischemic attack and diabetes,as well as the increased levels of serum C-reactive protein,uric acid,and homocysteine were the independent risk factors for cognitive impairment after ischemic stroke.
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Tne voxel-based morphometry(VBM)is a newly developed technique for brain morphometry in recent years.This article briefly expounds the concept,fundamental principle, advantages and disadvantages of VBM.It also reviews the preliminary applications of voxel-based morphometry in mild cognitive impairment and Alzheimer'S disease.