RESUMO
Laryngeal squamous cell carcinoma (LSCC) is the most common type of head and neck squamous cell carcinoma (HNSCC) worldwide. Protein phosphatase 2A (PP2A) dysfunction has been widely reported in a broad range of malignancies due to its distinctive role in miscellaneous cellular processes. However, it is poorly understood whether aberrant alterations of PP2A are involved in the network of oncogenic events in LSCC. Here, we detected a panel of PP2A-associated proteins using western blot in both laryngeal squamous cell carcinoma tissues and paired adjacent normal tissues from patients (Data S1). We found that phospho-PP2A/C (Y307), α4, cancerous inhibitor of protein phosphatase 2A (CIP2A), Akt, ezrin, phospho-ezrin (T567), 14-3-3, and focal adhesion kinase (FAK) showed increased expression levels in carcinoma tissues relative to normal tissues, while phospho-Akt (T308) showed decreased levels. Our study, thus, provides a rationale for targeting PP2A to develop novel therapies and proposes a combination of interrelated biomarkers for the diagnostic evaluation and prognosis prediction in LSCC.
Assuntos
Humanos , Autoantígenos/metabolismo , Biomarcadores Tumorais/metabolismo , Carcinoma de Células Escamosas/metabolismo , Estudos de Casos e Controles , Proteínas do Citoesqueleto/metabolismo , Quinase 1 de Adesão Focal/metabolismo , Perfilação da Expressão Gênica , Regulação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Peptídeos e Proteínas de Sinalização Intracelular/metabolismo , Neoplasias Laríngeas/metabolismo , Laringe/metabolismo , Proteínas de Membrana/metabolismo , Fosforilação , Proteína Fosfatase 2/metabolismoRESUMO
@#ObjectiveTo explore the clinical therapeutic effect of treating cervical vertigo induced by atlantoaxial joint malposition with manipulation.MethodsForty cervical vertigo cases induced by atlantoaxial joint malposition and diagnosed by palpating, X-ray examination, were treated with fixed-point manual reduction.ResultsThirty-one cases were cured, total effective rate was 100%.ConclusionManipulation can cure atlantoaxial joint malposition, relax vertebral artery, improve cerebrum blood supply, so it is available for cervical vertigo.