Compliance and curative effect and their correlation of comprehensive vision training in patients with amblyopia / 国际眼科杂志(Guoji Yanke Zazhi)

AIM:To analyze the compliance and curative effect of comprehensive vision training in patients with amblyopia. METHODS:A prospective study was conducted among 200 patients(294 eyes)with amblyopia who were treated in the hospital from July 2018 to August 2019. The patients were divided into a control group(98 patients, 140 eyes, traditional comprehensive vision training)and an experimental group(102 patients, 154 eyes, intelligent multi-dimensional comprehensive vision training)according to the random number table method. Curative effect, compliance, and the correlation between the two groups were observed.RESULTS:The overall response rate and compliance rate in the experimental group(93.5%, 45.1%)were higher than those in the control group(80.0%, 35.7%, all P<0.05). The curative effect was different in patients of different age, with different types and severity of amblyopia, different nature of fixation, and different compliance(all P<0.001). Age and the severity of amblyopia were negatively correlated with the curative effect(r=-0.342, -0.459, P<0.001), while compliance was positively correlated with the curative effect(r=0.378, P<0.001). Patients aged 3-6 had significantly better compliance, followed by those aged 7-10(P<0.05). Age was negatively correlated with treatment compliance(r=-0.398, P<0.001).CONCLUSION:Intelligent multi-dimensional comprehensive vision training can improve the compliance of patients with amblyopia, thereby achieving better curative effect. The curative effect is closely related to age, the type and severity of amblyopia, the nature of fixation and compliance. Compliance is related to age. Clinically, early treatment should be conducted bases on these features.

Recent progress in synthesis and pharmacological effects of ellipticine and its derivatives / 药学学报

Ellipticine is an alkaloid isolated from natural product with cytotoxicity, which has antitumor and anti-aids activity. Since it was first identified in 1959, a great deal of effort has been devoted to the development of various approaches for synthesis of ellipticine. This review provides a summary for synthesis approaches of ellipticine from different starting materials. The antitumor mechanism and structure-activity relationship are also discussed.