Research progress on application of gold magnetic nanocomposite in biomedicine / 生物医学工程学杂志

This paper provides a brief overview of the current research activities which focused on the bio-application of gold magnetic nanocomposite particles. By combining the magnetic characteristics of the iron oxide core with the unique features of nano-gold particles such as targeting by surface modification and optical properties, such composite nanoparticles have a wide range of applications in cancer hyperthermia, CT and MRI imaging, bio-separation, bio sensors, gene diagnosis, drug targeting and many other biomedical fields.

Particle swarm optimization fuzzy modeling and closed-loop anaesthesia control based on cerebral state index / 生物医学工程学杂志

Due to individual differences of the depth of anaesthesia (DOA) controlled objects, the drawbacks of monitoring index, the traditional PID controller of anesthesia depth could not meet the demands of nonlinear control. However, the adjustments of the rules of DOA fuzzy control often rely on personal experience and, therefore, it could not achieve the satisfactory control effects. The present research established a fuzzy closed-loop control system which takes the cerebral state index (CSI) value as a feedback controlled variable, and it also adopts the particle swarm optimization (PSO) to optimize the fuzzy control rule and membership functions between the change of CSI and propofol infusion rate. The system sets the CSI targets at 40 and 30 through the system simulation, and it also adds some Gaussian noise to imitate clinical disturbance. Experimental results indicated that this system could reach the set CSI point accurately, rapidly and stably, with no obvious perturbation in the presence of noise. The fuzzy controller based on CSI which has been optimized by PSO has better stability and robustness in the DOA closed loop control system.

Research progress on anti-tumor and immunity activity of CpG / 国际肿瘤学杂志

CpG motifs are unmethylated oligodeoxynucleotides,and its core sequences are composed of unmethylated cytosine and unmethylated guanine.CpG motifs can induce the immune response by activating a variety of immune cells against diseases.The changes of CpG structure will increase the biological activities of CpG,and then enhance the therapeutic effect of CpG as the immuno adjuvant and the sensitizer of radiotherapy and chemotherapy in cancer treatment

Dosimetric verification and clinical efficacy of intensity modulated radiotherapy in nasopharyngeal carcinoma / 中南大学学报(医学版)

OBJECTIVE@#To investigate dosimetric characteristics and to evaluate the clinical efficacy of intensity modulated radiotherapy (IMRT) as compared with conventional radiotherapy in nasopharyngeal carcinoma (NPC).@*METHODS@#Forty-seven NPC patients who accepted IMRT served as the IMRT group, and conventional radiotherapy plan was also made for each patient in this group using the treatment planning system. Dosiological evaluation of the 2 radiotherapy plans was made through dose volume histogram, 95% target volume dose (V(95)) and normal tissue complication probability. Another 47 patients who underwent conventional radiotherapy (CRT) at the same period formed the control group. The therapeutic effect as well as the acutes and late toxicities of normal tissues in the 2 groups were observed.@*RESULTS@#V(95) of the IMRT was more than 96% (96.83%-99.99%) for each target area, obviously superior to CRT in the sub-clinical target area. The radiation dose of normal tissues such as the brainstem and the spinal cord in the IMRT was much less than that in the CRT. Consistant with this, the part and complete remission rate, the 3-year loco-regional progress free survival rate, and overall survival rate in the IMRT group were all higher than those in the CRT group. For most patients in the IMRT group, the grade of acute toxicities was much lower than that in the CRT group. Patients in the IMRT group showed no more than grade 3 xerostomia, while in the CRT group still 21% of the patients suffered grade 3 or higher xerostomia a year later.@*CONCLUSION@#Compared with CRT, IMRT can improve the target volume dose and decrease the dose of surrounding tissues, resulting in higher control rate and fewer side effects.

Feature detection of tissue lesion in HIFU based on SOM / 生物医学工程学杂志

Noninvasive detection of tissue lesion is an important aided way in the process of high intensity focused ultrasound (HIFU) treatment. A new method is proposed for noninvasive detection of tissue lesion based on self-organizing maps (SOM) network. Tissue lesion, created by HIFU exposures, inevitably leads to change in B-mode image, since some new interfaces will appear in tissue. The difference-sub-image near focus of HIFU, where the tissue lesion appears, is used. Feature of lesion in difference-sub-image is extracted using the method based on SOM network. Experimental results show that the performance of the method proposed in this paper is better than that of others, such as the methods based on average gray, energy and standard deviation of difference-sub-image.

Removal of ocular artifact from EEG based on JADE / 生物医学工程学杂志

The method of Joint approximate diagonalization (JADE) is used to remove the ocular artifact from Electroencephalogram (EEG). As the JADE algorithm can be used to separate sub-gaussian and super-gaussian sources, it is possible to extract the signals that are statistically independent, and to identify the spatial map that is associated with the artifactual component. Thus the method can remove artifactual component. Satisfactory results illustrate the robust and practicability of the algorithm.

Design of a cardiac monitoring system using mobile communications / 生物医学工程学杂志

Telemedicine is gaining more and more momentum as a new approach for patients'surveillance. In many monitoring parameters, electrocardiography is the most important, especially for monitoring patients with serious cardiovascular diseases. They need to be monitored frequently in order to detect any deterioration. In this paper,we design a electrocardiographic telemetry system using General Packet Radio Service(GPRS). This design adds to traditional Holter capability of monitoring the patients'heart anywhere, anytime.

Method for detecting ECG arrhythmia / 医疗卫生装备

Usually, the frequency of heartbeat can be used to discriminate different kinds of arrhythmia from a normal cardiac rhythm, but the result is not satisfying. This paper presents a method that can differ ventricular fibrillation (VF) and ventricular tachycardia (VT) from a normal sinus rhythm (NSR). VT and VF are fatal arrhythmia for patients, but timely electroshock is a good remedy for them. The method above can be integrated into the monitor system or telemedicine to diagnose patients and then treat them properly. With auto regressive (AR) model applied to modeling, Itakura and Euclidian distance measurements are used to classify data. With this method, VF and VT conditions are detected with error less than 10%.