Long-term efficacy and safety of telbivudine in the treatment of childbearing patients with chronic hepatitis B / 中华肝脏病杂志

<p><b>OBJECTIVE</b>To observe the long-term efficacy and safety of telbivudine (LdT) for pregnant women with chronic hepatitis B (CHB) and their children born from the treatment period.</p><p><b>METHODS</b>A total of 118 pregnant women with CHB were enrolled in the study and provided informed consent for participation. The women opted for participation in the treatment group (7 =73; LdT 600 mg once daily, starting in early pregnancy and continued until after delivery) or in the control group (n =45; no LdT treatment). All newborns were given active and passive immunization upon birth and tested for serum hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), anti-hepatitis B core antibody (anti-HBc), anti-hepatitis B surface antibody (anti-HBs) and HBV DNA at 0, 1, 7 and 12 months of age. The Paediatrics Neuropsychological Development Scale for Children aged 0 - 6 (5 items) established by the Capital Institute was used to test the children; in addition, the children were evaluated by observation for action ability (fine and gross motor skills), adaptability, language ability and social behaviour. Total IQ was estimated as a developmental quotient (DQ) by using the equation: points from the 5 scale items actual age in months * 100.</p><p><b>RESULTS</b>The LdT group included 69 women with successful pregnancies, 1 case of miscarriage and 3 cases that were lost to follow-up. The control group included 34 women with successful pregnancies, 4 cases of miscarriage, 1 case with fatal outcome, and 6 cases of no pregnancy. Compared to the control group, the LdT group had a significantly higher successful pregnancy rate (x² =4.86 in the LdT group, P < 0.05). In addition, the LdT group had a significantly higher rate of term delivery (53 cases vs. 34 cases, x² = 6.38, P < 0.05). The neonates born to the women in the LdT group included 53 cases of weakly-negative HBsAg at birth and 1 case at 1 month old, as well as negativity for HBV DNA, and HBsAg remaining weakly positive at 6 months old; the intrauterine infection rate was 1.8% and no case of deformity occurred.Among the 34 neonates in the control group, 6 showed HBsAg positivity at 1 month old, and the HBsAg positivity remained for all 6 at 6 months old; the intrauterine infection rate was 16.6%, which was significantly higher than that of the LdT group (x² = 5.10, P < 0.05). The neonates in the LdT group had a significantly higher anti-HBs production rate at 1 year old than those in the control group (98.1% (52/53 vs. 82.4% (28/34). X² = 4.87, P < 0.05). The neonates in the LdT group showed normal growth and development for all 53 cases of young children, and IQ levels of excellent for 3 cases, smart for 8 cases, normal for 40 cases, and low for 2 cases. The neonates in the control group showed normal growth and development for all 34 cases of young children, and IQ levels of excellent for 2 cases, smart for 4 cases, normal for 27 cases, and low for 1 case.</p><p><b>CONCLUSION</b>Childbearing chronic HBV patients treated with LdT had higher rates of successful pregnancy, blocking of intrauterine infection and anti-HBs reduction compared to their untreated counterparts. The children bom to LdT-treated women showed no difference in long-term growth and development and total IQ from the children born to the untreated women with chronic HBV.</p>

The reliability and validity of the Chinese version of the Cambridge Prospective Memory Test with Chinese brain injured patients / 中华物理医学与康复杂志

Objective To evaluate the reliability and criteria validity of the Chinese Cambridge Prospective Memory Test (C-CAMPROMPT) for testing Chinese patients with acquired brain injury. Methods The CAMPROMPT was translated into Chinese. The translated Version was then used with 30 'normal persons' and 39 with acquired brain injury and memory problems. Correlation analysis and Cronbach's a were used to evaluate reliability and criteria validity of the C-CAMPROMPT. Results Correlation and Cronbach's a were in the range 0.697 to0.951.The total and event-based scores were positively corrlated with all three field Chinese Version of Rivermead Behavior Memory Test scores. Time-based C-CAMPROMPT scores,however,were negatively correlated with Chinese Version of the Stroop Word-Color Test results. Conclusion The reliability and validity of the C-CAMPROMPT were high enough to be used to test the prospective memory of acquired brain injury patients in the clinic.