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Objective:To investigate the relationship between normal plasma fibrinogen(FIB)levels and disease duration in elderly patients with type 2 diabetes mellitus(T2DM).Methods:Clinical data and biochemical test results of 1 116 elderly subjects with T2DM admitted to the Department of Endocrinology of Shanghai Tianyou Hospital from January 2016 to October 2019 were retrospectively collected and analyzed.Subjects were classified into four groups based on the duration of DM: the Q1 group(n=276, < 2.0 years), the Q2 group(n=278, 2.0-7.9 years), the Q3 group(n=280, 8.0-13.9 years)and the Q4 group(n=282, ≥ 14.0 years). The correlation between FIB and the duration of DM was analyzed.Results:With the prolongation of DM duration, FIB levels increased significantly( P<0.05). Pearson correlation analysis showed that the duration of DM was positively correlated with FIB, age and serum creatinine( P<0.01). Multiple stepwise regression analysis showed that the duration of DM was an independent factor for FIB( β=0.104, P<0.01). Logistic multiple regression analysis showed that after adjusting for sex, age, body mass index, systolic pressure, diastolic pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, serum creatinine, alanine aminotransferase, fasting plasma glucose, glycosylated hemoglobin, smoking and drinking, the risk of hyperfibrinogenemia was 2.436 and 2.104 times higher, respectively, in Group Q4 and Group Q3 than in Group Q1(95% CI: 1.317-4.507, P<0.01; 95% CI: 1.144-3.871, P<0.05). With the third-quartile FIB(3.70 g/L)as the cut-off value, the optimal cut-off point of the DM course was 9.5 years as calculated by receiver operating characteristic(ROC)curve analysis of DM duration and hyperfibrinogenemia. Conclusions:The FIB level is positively correlated with DM duration in elderly patients with T2DM.
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Objective To investigate the relationship between serum levels of D-dimer(DD),hs-CRP and IL-6 with the infarction severity and prognosis in the patients with cerebral infarction(CI),and to analyze the influencing factors of prognosis for screening the independent risk factors affecting prognosis.Methods Eighty-one patients with CI in our hospital from January 2014 to June 2015 were selected as research subjects.All patients were treated with the CI routine treatment after admission.On admission,the CI severity was assessed by NIHSS,the serum levels of DD,hs-CRP and IL-6 were detected.After discharge,following up lasted for 12 months,the prognosis was assessed by MRS scale.The correlation between DD,hs-CRP and IL-6 with the infarction severity and prognosis was analyzed.The prognostic influencing factors were analyzed by adopting the univariate analysis and multivariate Logistic regression analysis.Results On admission,the levels of DD,hs-CRP and IL-6 in the severe group were significantly higher than those in the moderate group(q=5.736,7.772,4.757,P<0.05) and the mild group(q=11.094,16.920,12.255,P<0.05),while the moderate group was significantly higher than the mild group(q=5.783,9.870,8.049,P<0.05).Pearson′s analysis showed that the levels of DD,hs-CRP and IL-6 were positively correlated with the CI severity(r=0.603,0.457,0.394,P<0.05).After following up for 12 months,the levels of DD,hs-CRP and IL-6 in the good prognosis group were significantly lower than those in the poor prognosis group(t=4.775,3.101,2.910,P<0.05).Pearson′s analysis showed that DD,hs-CRP and IL-6 levels were positively correlated with poor prognosis(r=0.584,0.513,0.432,P<0.05).Multiple Logistic regression analysis showed that infarct volume,NIHSS score,DD,hs-CRP and IL-6 were the independent risk factors for poor prognosis in the patients with CI(P<0.05).Conclusion The infarct volume,NIHSS score,DD,hs-CRP and IL-6 are the independent risk factors for poor prognosis in the patients with CI,which provide a certain reference for judging the prognosis in CI patients.