Applications and prospects of holographic projection in medical field and medical education / 中华医学教育探索杂志

Firstly, this paper introduces the classification of holographic projection by its concept and characteristics. Secondly, this paper investigates the present application status in medical fields like virtual surgery, medical diagnosis, telemedicine, doctor-patient communication, etc. It also analyzes the feasibility of applying this technology into medical education from three aspects of basic medicine, clinical medicine, and remote instruction.

Cordycepin protects against β-amyloid and ibotenic acid-induced hippocampal CA1 pyramidal neuronal hyperactivity

Cordycepin exerts neuroprotective effects against excitotoxic neuronal death. However, its direct electrophysiological evidence in Alzheimer's disease (AD) remains unclear. This study aimed to explore the electrophysiological mechanisms underlying the protective effect of cordycepin against the excitotoxic neuronal insult in AD using whole-cell patch clamp techniques. β-Amyloid (Aβ) and ibotenic acid (IBO)-induced injury model in cultured hippocampal neurons was used for the purpose. The results revealed that cordycepin significantly delayed Aβ + IBO-induced excessive neuronal membrane depolarization. It increased the onset time/latency, extended the duration, and reduced the slope in both slow and rapid depolarization. Additionally, cordycepin reversed the neuronal hyperactivity in Aβ + IBO-induced evoked action potential (AP) firing, including increase in repetitive firing frequency, shortening of evoked AP latency, decrease in the amplitude of fast afterhyperpolarization, and increase in membrane depolarization. Further, the suppressive effect of cordycepin against Aβ + IBO-induced excessive neuronal membrane depolarization and neuronal hyperactivity was blocked by DPCPX (8-cyclopentyl-1,3-dipropylxanthine, an adenosine A₁ receptor-specific blocker). Collectively, these results revealed the suppressive effect of cordycepin against the Aβ + IBO-induced excitotoxic neuronal insult by attenuating excessive neuronal activity and membrane depolarization, and the mechanism through the activation of A₁R is strongly recommended, thus highlighting the therapeutic potential of cordycepin in AD.

Evaluation of the reliability and validity of the Chinese version of Glasgow children's benefit inventory / 中国耳鼻咽喉头颈外科

OBJECTIVE One of the objective of the study was to analyze the reliability and validity of the Chinese version of Glasgow children's benefit inventory (GCBI). The other was to explore whether the Chinese version of GCBI could be used as a appropriate evaluation method on children's quality of life (QOL) after tonsillectomy and adenoidectomy (T&A). METHODS Firstly, seventy-three eligible children and their proxies were interviewed with this survey scale, the survey scale was assessed by split-half reliability, internal consistency, content validity and construct validity. Second, the Chinese version of GCBI used to evaluate the changes of these 73 children's QOL at 12 to 18 months after operation. RESULTS First, the reliability coefficient and the construct validity of the Chinese version of GCBI was satisfactory. Second, almost all children's QOL changed better after operation, it improved the most in physical aspects. CONCLUSION The Chinese version of GCBI had good reliability and validity, and is suitable for assessing QOL of children after T&A. It can help clinician evaluate therapeutic effect in pediatric otolaryngology.

Value of heart murmurs and transcutaneous oxygen saturation in screening for neonatal congenital heart disea-ses / 中华实用儿科临床杂志

Objective To compare the importance of heart murmurs and transcutaneous oxygen saturation (SpO2)in screening neonatal congenital heart diseases(CHD),and to explore a reliable and easy-to-use method for the screening of CHD. Methods All infants (16 070 cases) born in Changzhou Maternal and Child Health Hospital from May 1 st 2011 to April 30 th 2013 were screened of CHD for heart murmurs and SpO2 . The screen-positive infants were divided into 3 groups:heart murmurs group,abnormal SpO2 group and mixed group. All screen-positive infants re-ceived cardiac color ultrasound to make a definite diagnosis of CHD,so as to compare the values of heart murmurs and SpO2 . Results Eight thousand seven hundred and ninety-nine boys and 7 271 girls were screened,in which the ratio was 1. 21:1. 00. One hundred and eighteen infants were screened positive,including 76 murmurs of which 45 were confirmed as CHD,28 with abnormal SpO2 of which 18 were confirmed and 14 mixed of which 13 were confirmed,so the confirmation rates were 59. 21%,64. 29% and 92. 86%,respectively. The diagnostic rate of CHD in mixed group was higher than other 2 groups,which had statistical significance(P=0. 045). The top three formation types of CHD were ventricular septal defect (VSD) (29/76 cases,38. 16%),patent ductus arteriosus (PDA) (13/76 cases, 17. 11%) and atrial septal defect (ASD) (11/76 cases,14. 48%). Conclusions The combination of heart murmurs and SpO2 was useful in increasing detection and decreasing misdiagnosis of CHD.

Analysis of monitoring information about infant congenital heart disease in Changzhou / 中华全科医师杂志

Screening of CHD of infants (11 178) born from May 1st 2012 to April 30th 2013.92 infants were screening positive,68 were diagnosed.The detectable rate of CHD was 6.08‰,while boys were 3.31‰,girls were 2.77‰.68 CHD patients,the top three were VSD(2.14‰),PDA(1.34‰) and ASD (0.89‰).In these infants,detectable cardiac souffle were 61,abnormal pulse oximetry were 40.The detectable rate of CHD among infants was identical compare the average level of whole country,but the distributional characteristics was disparity.The screening of CHD was feasible,and cardiac souffle and pulse oximetry were recommended.

Follow-up of 103 infants with congenital heart disease in Changzhou / 临床儿科杂志

Objective To establish a system of the screening, evaluation and intervention of congenital heart disease (CHD) in China. Methods All infants (16070) born in Changzhou Maternal and Child Health Hospital from May 1st 2011 to April 30th 2013 were screened for CHD. The infants with CHD were followed up till 1 year of age. Results One hundred and three infants were diagnosed with CHD, and the incidence rate was 0.641%. The top three CHD types in incidences were VSD (0.205%), PDA (0.174%) and ASD (0.10%), respectively. In these infants, 94 cases were followed-up and 9 cases were lost. The incidence of small gapped VSD, ASD and premature PDA were high. Some infants with serious CHD were subjected to surgery, and others were still followed up. Conclusions The incidence of CHD in Changzhou is comparable with that in the whole country. The follow-up can improve the life quality of CHD infants.

Feasibility of constructing a screening-evaluating-intervention system of congenital heart disease in Changzhou city / 中华实用儿科临床杂志

Objective To investigate the prevalence and the distribution of congenital heart disease(CHD) in Changzhou city.The clinical data of 106 CHD infants were reviewed,so as to provide some evidence for making CHD screening-evaluating-intervention system.Methods All infants(16 070 cases) born in Changzhou Maternal and Child Health Hospital from May 1st 2011 to Apr.30th 2013 were screened for CHD.The infants with CHD were followed up for one year periodically after discharge.Results One hundred and seventeen infants were screened positive,and 106 cases of them were diagnosed as CHD,and the detectable rate was 6.60‰.The top three incidence was VSD (2.18‰,35/16 070 cases),PDA(1.74‰,28/16 070 cases) and ASD(1.06‰,17/16 070 cases).Among them,81 cases were detected as cardiac souffle,and 48 cases as abnormal pulse oximetry.In 106 cases,97 cases were followed up and 9 cases did not receive follow-up.The close ratio were higher in ASD,PDA,VSD,which was 76.47％,64.29％,62.86％.The size of gap had an effect on close ratio,small gap of VSD,ASD and premature PDA were higher and medium and large gap and full-term infants were lower.Some serious type of CHD infants received operations,and others were still followed up.Conclusion The detectable rate of CHD among infants was identical to the average level of whole country.The follow-up study may improve the quality of the survival of CHD infants,and it is feasible to construct a system of screening-evaluating-intervention systcm of CHD.

Serum S-100B concentration of umbilical cord blood in the early diagnosis of newborn hypoxic ischemic encephalopathy / 中国综合临床

Objective To investigate the role of serum S-100B of umbilical cord blood in the early diagnosis of newborn hypoxic ischemic encephalopathy(HIE).Methotis 307 full-term newborns with asphyxia were selected as subiects and 43 normal full-term newborns delivered during the corresponding period were selected as controls.The umbilical cord blood sample was acquired.46 cases of 307 subjects with asphyxia developed into HIE,31 cases with mild HIE and 15 cases with moderate and severe HIE.The serum S-100B concentration of umbilical cord blood was detected by ELISA analysis.Results ①There was no significant difference in the serum S-100B concentration of umbilical cord blood between the male sub-group and female sub-group in normal group;②The concentration in control group and HIE group were(1.03±0.32)μg/L and(2.53±1.1)μg/L respectively(t=8.848,P＜0.05＝;③The concentration in mild HIE group and moderate to severe HIE group were(1.03±0.32)μg/L nd(3.49±1.23)μg/L respectively,which were significantly different with control group(F=79.6909,P＜0.01).Conclusion Sex has no significant relation to the serum S100B concentration.Serum S-100B concentration of umbilical cord blood can be biomarkers for early diagnosis of newborn HIE.