MUTAGENICITY AND ANTIMUTAGENICITY OF MEDICINAL PLANTS, NOM NANG, SUN SOKE AND STEVIA, EXTRACTS IN AMES TEST

Abstract Aqueous and 80% alcohol crude extracts of three medicinal plants, i.e., Nom Nang , Sun Soke and Stevia showed non-genotoxicity in Ames test in the presence or absencc of metabolic enzymes activation. However, the aqueous and 80% alcoholic extracts of Sun Soke or Nom Nang showed antimutagenicity against pyrolysate mutagens, IQ and Trp-P-1, hepatocarcinogen, aflatoxin B1 and a carcinogenic, AF-2. But co-mutagenicity to Trp-P-1 was observed in 80% alcoholic extract of Nom Nang and to AFB1 was in aqueous extract of Sun Soke. Chiang Mai Med Bull 2001;40:(3):147-153.