RESUMO
Ginsenoside Rg3,the active ingredient of ginseng with obvious anti-tumor effect,can effectively inhibit the growth of lung cancer,gastric cancer,liver cancer,colon cancer and breast cancer,and improve the immunity. However,ginsenoside Rg3 has poor water solubility with slow absorption and rapid elimination,which leads to low plasma concentration and low bioavailability. Thus,how to overcome its low solubility and improve its bioavailability has become an important research area. In this paper ,the dos-age forms of ginsenoside Rg3 are reviewed by consulting relevant publications.
RESUMO
Superparamagnetic iron oxide nanoparticles(SPION) as a new type of nano-materials have been widely studied. Because of their superparamagnetic property, targeting, biocompatibility, easy observability, and plasticity, etc., SPION have been used not only as magnetic resonance imaging (MRI) contrast agents in the early diagnosis of clinical cancer, but also as targeting drug carrier to selectively deliver the drugs especially anti-cancer drugs to target lesion, and therefore, improve the bioavailability of the drugs. For these reasons, the research on contrast agents and magnetic targeting drug carrier has attracted widespread attention. This paper reviews the research progress of SPION application in MRI and targeted drug delivery through consulting a number of relevant publications.