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1.
Journal of Rheumatic Diseases ; : 214-218, 2014.
Artigo em Coreano | WPRIM | ID: wpr-190173

RESUMO

Ankylosing spondylitis (AS) is a chronic inflammatory disorder, commonly characterized by inflammation of axial skeleton and development of enthesopathies. Tumor necrosis factor inhibitors (TNFi) shows good therapeutic responses in AS patients without good response to non-steroidal anti-inflammatory drugs. Although TNFi are relatively safe for AS patients, serious opportunistic infections, including tuberculosis and fungal infection, could develop. Here, according to our knowledge, we report a first Korean case of pulmonary cryptococcosis in a patient with AS treated with etanercept. A 64 year-old man with AS visited due to a newly appeared pulmonary nodule on a routine chest radiography. He had been administered etanercept for 5 months. Histologic findings of the lung nodule showed characteristic features of cryptococcosis. Etanercept was discontinued and oral fluconazole was administrated, as there was no evidence of central nervous system involvement. After 7 months of treatment, chest CT showed an improvement of the pulmonary lesion.


Assuntos
Humanos , Sistema Nervoso Central , Criptococose , Fluconazol , Inflamação , Pulmão , Infecções Oportunistas , Radiografia , Doenças Reumáticas , Esqueleto , Espondilite Anquilosante , Tórax , Tomografia Computadorizada por Raios X , Tuberculose , Fator de Necrose Tumoral alfa , Etanercepte
2.
Yeungnam University Journal of Medicine ; : 52-55, 2014.
Artigo em Inglês | WPRIM | ID: wpr-30785

RESUMO

Protein S deficiency is one of the several risk factors for thrombophilia and can cause blood clotting disorders such as deep vein thrombosis and pulmonary embolism. A 54-year-old man was admitted with the complaint of dyspnea and was diagnosed with pulmonary embolism. The patient had very low level of free protein S, total protein S antigen, and protein S activity (type I protein S deficiency). In history taking, we found that his mother, 78 year old, had a history of same disease 10 years ago, and confirmed the pronounced low level of protein S. The patient's son also had very low level of protein S, however there had not been any history of pulmonary embolism yet. This case study suggests that asymptomatic persons with a family history of protein S deficiency and pulmonary embolism should be checked regularly for early detection of the disease, as protein S deficiency can be suspected.


Assuntos
Humanos , Pessoa de Meia-Idade , Coagulação Sanguínea , Dispneia , Mães , Proteína S , Deficiência de Proteína S , Embolia Pulmonar , Fatores de Risco , Trombofilia , Trombose Venosa
3.
Korean Journal of Medicine ; : 774-780, 2014.
Artigo em Coreano | WPRIM | ID: wpr-85484

RESUMO

Post-transplantation lymphoproliferative disorder (PTLD) is a serious complication that can develop after either solid organ or hematopoietic stem cell transplantation (HSCT). The incidence of Hodgkin's lymphoma (HL) ranges from 0.5-1.0% of PTLD after HSCT without T-cell depletion. Here, we report a case of HL-PTLD that occurred after autologous peripheral blood stem cell transplantation for an angioimmunoblastic T-cell lymphoma (AITL). A 36-year-old patient developed fever and chills with multiple lymphadenopathies at day 673 after auto-HSCT for AITL. Three months after the transplant, the patient developed fever with elevated plasma Epstein-Barr virus (EBV)-PCR values. The excisional biopsy revealed HL at Ann Arbor stage IIIB. A total of 8 cycles of chemotherapy with ABVD please define were performed, and the patient has remained disease-free. To our knowledge, this is first case report of HL-PTLD after auto-PBSCT in Korea.


Assuntos
Adulto , Humanos , Biópsia , Calafrios , Tratamento Farmacológico , Febre , Transplante de Células-Tronco Hematopoéticas , Herpesvirus Humano 4 , Doença de Hodgkin , Incidência , Coreia (Geográfico) , Linfoma de Células T , Transtornos Linfoproliferativos , Transplante de Células-Tronco de Sangue Periférico , Plasma , Linfócitos T
4.
Journal of the Korean Society of Emergency Medicine ; : 469-472, 2013.
Artigo em Coreano | WPRIM | ID: wpr-112419

RESUMO

Podostroma cornu-damae is a rare species of fungus belonging to the Hyocreaceae family. Its fruit body is highly toxic, as it contains trichothecene mycotoxins. Unfortunately, it highly resembles Ganoderma lucidum and Cordyceps, well-known health foods; this can lead to poisoning. We experienced such a case of a 42-year old man who received mushroom poisoning by injesting Podostroma cornu-damae. The patient was presented with severe pancytopenia and infection. The patient recovered without any complications after conservative care, antibiotics therapy, and granulocyte colony stimulating factor administration. The most common complications of podostroma cornu-damae intoxication were reported pancytopenia, infection, disseminated intravascular coagulation, acute renal failure, etc. It is important to provide enough fluid therapy, use of antibiotics to infection and granulocyte colony stimulating factor administration.


Assuntos
Humanos , Injúria Renal Aguda , Agaricales , Antibacterianos , Fatores Estimuladores de Colônias , Cordyceps , Coagulação Intravascular Disseminada , Hidratação , Frutas , Fungos , Granulócitos , Intoxicação Alimentar por Cogumelos , Micotoxinas , Pancitopenia , Reishi , Tricotecenos
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