Acute Lymphoblastic Leukemia with Treatment–Naïve Fanconi Anemia.

Fanconi anemia is known to have a predisposition to cancer, mostly associated with acute myeloid leukemia. We report an eight-year-old girl with treatment and naïve FA who developed acute-lymphoblastic-leukemia (ALL). She was initiated on chemotherapy but she failed to respond to treatment and died during induction phase of chemotherapy. While this association may be coincidental but possibility of transition of Fanconi anemia to ALL should be considered in view of high predisposition to cancer in this disorder.