RESUMO
Nitric oxide is a product of the conversion of L-arginine by the enzyme nitric oxide synthase. Nitric oxide is involved in a variety of physiological situations and is produced by many different cell types. It is involved in neurotransmission, maintenance of vascular smooth muscle tone, and cytotoxicity. Nitric oxide has been suggested to play an anti-inflammatory role by inhibiting the expression of the genes for inflammatory cytokines. The pathophysiological role of nitric oxide is also evident in a variety of diseases, including septic shock, asthma, reperfusion injury, etc. Nitric oxide, by stimulating the production of cyclic GMP, relaxes smooth muscles of the cardiovascular, respiratory, gastrointestinal, and genito-urinary systems. Recent studies have provided important information on the use of inhaled nitric oxide for the management of several diseases characterized by the presence of abnormal pulmonary vascular tone, such as persistent pulmonary hypertension of the newborn. This review addresses the biology and clinical uses of inhaled nitric oxide.
Assuntos
Criança , Humanos , Recém-Nascido , Pulmão/irrigação sanguínea , Óxido Nítrico/administração & dosagem , Síndrome da Persistência do Padrão de Circulação Fetal/tratamento farmacológico , Resistência Vascular/efeitos dos fármacosRESUMO
Hemagglutination inhibition tests for antibody against chikungunya virus and the four dengue viruses were performed on a rural Thai village population. The 50% and 90% prevalence indices fell at about ages 3 and 15 for dengue virus exposure. This is considerably earlier exposure than comparable urban populations. The prevalence of chikungunya virus antibody was also age related with 50% prevalence at about age 45.