RESUMO
We report a 50 year old man with lumbar canal stenosis proved on myelography, who presented with hesitancy, constipation and numbness in the "saddle area", with mild and transient lumbago and no claudication. His symptoms improved over several months after surgery.
Assuntos
Constipação Intestinal/etiologia , Humanos , Vértebras Lombares , Masculino , Pessoa de Meia-Idade , Síndromes de Compressão Nervosa/etiologia , Raízes Nervosas Espinhais , Estenose Espinal/complicações , Transtornos Urinários/etiologiaRESUMO
3,4-Dihydroxyphenyl ethylene glycol (DOPEG), a metabolite of noradrenaline (NA), was estimated in CSF of 30 patients of depression diagnosed by the criteria of American Psychiatric Association in DSM-III; and compared with levels in 10 non-depressed individuals who served as controls. Mean DOPEG levels in CSF in the patient group (801.37 +/- 28.09 micrograms/l) were significantly higher (P less than 0.01) than those in the control group (724.3 +/- 34.62 micrograms/l). Formation of excessive amount of this particular metabolite suggests an excessive intraneuronal deamination of NA, partially accounting for the overall decline in the availability of NA in the noradrenergic neurons in patients of depression.