Two Cases of Xanthogranuloma in Adults / 대한피부과학회지

Recently, we have experienced two cases of xanthogranuloma in adults presenting either a solitary papule or multiple papules. Laboratory findings including blood lipid substances such as cholesterol and triglyceride were within normal limits. In both cases, we could not find any other extracutaneous manifestations. Granulomatous infiltrates containing foam cells, foreign body giant cells and Touton giant cells as well as histiocytes and lymphocytes were revealed by histopathologic findings.

A Case of Inverted Follicular Keratosis

I report a case of inverted follicular keratosis in a 68-year-old woman who presented a solitary, asymptomatic, slightly brownish verrucous nodule on her nose, present for 3 years. The lesion was characterized histologically by focal hyperkeratosis, marked acanthosis, horn cysts, numerous squamous eddies and sebaceous differentiation of the basaloid cells in the epidermis.

Contact Urticaria - Relationship between Blocking Effect to Wheal Formation and Antiinflammatory Potencies of Some NSAID / 대한피부과학회지

This study was undertaken to investigate the response of non-immunologic contact urticaria(NICU) test before and after ingestion of cyclo-oxygenase inhibitors such as naproxene, ibuprofen and mefenamic acid. Forty patients who showed positive reaction to 5% benzoic acid (BA) in petrolatum by 20 minutes closed patch test were chosen and divided into 3 groups. Group I was consisted of 13 patients who were taken naproxene 250mg bid, group II, 14 patients, taken ibuprofen 600mg bid, and group III, 13 patients, taken mefenamic acid 500mg bid. All the patients were tested with 5%, 2.5%, 1%, 0.5% and 0.1% BA in petrolatum using Finn chamber on Scanpor tape on the right arm before medication and next day on the left arm after medication of each day. Mefenamic acid did not show any significant differences before and after ingestion of drug. Naproxene reduced reaction about half of patients. Ibuprofen reduced reaction in almost all patients and blocked reaction completely in 9 of 13 patients. This results suggested that there was no correlation between blocking effect to BA induced contact urticaria and so called anti-inflammatory potencies of naproxene and ibuprofen, and that NICU by BA is partly mediated by prostaglandins(PG) or mediated by other mediators, which were potentiated by PG, except histamin.

A Case of Becker's Nevus Associated with Smooth Muscle Hamartoma / 대한피부과학회지

We report a case of Becker's nevus associated with smooth muscle hamartoma, in a 21-year-old male patient, which shows clinically match-head sized, flat topped, round to oval, grouped papules with hairs on the outer surface of the right arm, and microscopically reveals numerous bundles of smooth muscle fiber in the dermis.

Assessment of Atrophy of Human Epidermis Caused by Various Corticosteroids Using Chamber Occlusion and Histometry / 대한피부과학회지

The aim of this stud y was to compare the epidermal thinning properties of four corticosteroid ointments applied under occlusion, using histology and histometry. The results were surnmerized as follows: 1.The stratum corneurn was dramatically thinned, appearing as a wispy layer of horny cells as apposed to the norrnal basket-weave configuration. this effect was prominent at sites treated with clobestasol propionate, fluocinonide, and fluocinolone acetonide. 2. With the histometry, visible epidermal thickness wa.s markedly reduced. This effect w is prominent in the following ascending order: fluocinolone acetonide, fluocienonide, clobestasol-17-propionate. Hydrocortisone was the least atrophogenic. 3. Clohestasol-17-propionate and fluocinonide caused significant flattening of dermo-epidermal junction, Fluocinolone acetonide and hydrocortisone caused less pronounced cbanges. 4. Marked capillary dilation af papilly dermis is caused by clobestasol-17-propionate, fluocinonide and fluocinolone acetonide.

Contact Urticaria: Etiology and Blocking Effect of Some Drugs / 대한피부과학회지

This study was undertaken to investigate the response of nonimmunologic contact urticaria(NICU) test before and after ingestion of cimetidine, homoclorcyclizine and indomethacin. Thirty-five patients who showed positive reaction to 5% benzoic acid (BA) in petrolatum (pet) by 20 minutes closed patch test were chosen and divided into 4 groups. Group I was consisted of 10 patients who were taken cimetidine 200 mg single dose, group 2, 9 patients, taken hornoclorcyclizine 10mg single dose or 30mg divided dose, group 3. 8 patients, taken indomethacin 100 mg single dose and group 4. 8 patients, taken indomethacin 50 mg tid. All the patients were tested with 5%. 2.5%. l%, 0.5%, and 0. l% BA in pet using Leukotape on the riight arm before rnedication and next day on the left arm after medication of each drug. Cimetidine and homoclorcyclizine did not show any significant differences before and after ingestion of drugs. Indomethacin, the cyclo-oxygenase inhibitor, blocked the reaction completely in half of the patients and reduced the reaction in almost all patients, regardless of doses. This results suggested that NICU induced by BA is not mediated by histamine but probably by prostaglandins.

Provocation Test of Non-Immunologic Contact Urticaria / 대한피부과학회지

This study was undertaken to investigate to compare the ratio of positive reactions to benzoic acid(BA), sorbic acid(SA) and cinnamic acid(CA) which are well known materials producing non-immunologic contact urticaria. Various concentrations(0.l% to 5%) and different vehicles(petrolatum, water, hydrophilic ointment base) were used in open and 20 minutes closed test using Finn chamber on Scanpor tape. One hundred total subjects were consisted of nonallergic patients and normal persons. The results were as follows ; 1. Total numbers of positive reactions were 69 in closed test(CT) and 60 in open test(OT), regardless of the materials and vehicles. 2. Total riumbers of positive reactions in BA, SA and CA were 68, 31, 35 in CT and 59, 20, 14 in OT respectably. 3. CT showed much more positive reactions than OT with all materials tested except 0.l% SA in water. 4. Hydrophilic ointment base showed a better reactivity than any other vehicles in CT. But in OT, petrolatum, water, hydrophilic ointment base showed better reactivity in BA, SA, CA respectably. 5. Almost all the reactions appeared within 45 minutes and disappeared within 3 hours. Erythema preceded edema and persisted 30 minutes to 1 hour after dissappearance of edema. 6 Itching, burning and tingling sensation were the only symptoms observed except. localized erythema and edema.

Epoxy Resin Contact Dermatitis / 대한피부과학회지

Epoxy resins,which are irritant and allergen, are now used for surface coatings, electrical insulations, adhesives, and construction industry throughout the world. However, epoxy resin contact dermatitis has not been reported in the Korean literature. We report two cases of epoxy resin contact dermatitis which were occupationally related. They have been in the same work, painting dye and resin mixtures on the glasses for decoration. They showed positive patch test reactions to epoxy resin 1, and their own materials containing resins and accelerators which were proved to be -countinue-

An Epidemiological Study of Contact Dermatitis / 대한피부과학회지

Numerous studies on epidemiological aspects of contact dermatitis have been published in recent years since the introduction of a standardized method of patch test. We have performed the patch test on patients with contact dermatitis and on patients with other forms of dermatitis, A total of 153 patients were tested in this study between January 198l and August 1982. We have routinely attached 29 Hollister's standard batteries and 0. l% Tego, which is a commonly used antiseptic in our hospital, to the patients back. The tapes used were Leukotape and Finn chamber. Forty-eight hours after the tape had been attached, the patches were removed and read. The second reading was taken 24 or 48 hours after the patch had been removed. According to the results of this study, the most common allergens were cinnamic alcohol (11. 1%), ammoniated mercuric chloride (10. 5%), nickel sulfate (9. 2%), hydroxycitronellal(6. 5%), paraben mix(5. 9%), mercaptobenzothiazole(5. 9%) and thimerosal(5. 9%). In conclusion, cosmetics, metals, medicaments and rubber compounds were found to be the most common etiologic agents of contact dermatitis in this studyBackground and possible explanation of these rusults were discussed and a comparison was made between this report and others.

A Case of REM (Reticular Erythematous Mucinosis) Syndrome / 대한피부과학회지

We present a case which seems identical to REM(Reticular Erythematous Mucinosis) syndrome in 26 year-old male. The lesion was initiated about 2 years ago and waxed and waned. The clinical findings were localized, grouped, erythematous papules and vesicles on the anterior middle chest with intermittent mild itching. Histopathology showed normal epidermis, extensive mucin deposition, telangiectasia and mild perivascular round cell infiltrations on the upper dermis. The mucin was stainable with alcian blue at pH 2. 5, but was not stained by either PAS or mucicarmine. Skin lesions were not responded to the oral steroid, but improved slowly after topical application of 5% para-aminobenzoic acid in ethanol for 9 months. The lesion does not recur until present time.

Quaternium-15 Contact Dermatitis / 대한피부과학회지

Quaternium-15 (Dowicil 200) which is a water-soluble antimicrobial agent and a formaldehyde releaser is widely being used as a preservative in cosmetics and medicaments these days. However, there are scanty reports about it in the Korean literature. Recently, we have experienced two cases of Quaternium-15 contact dermatitis probably related with their cosmetics and topical medicament, respectively. We report our cases with the patch test results.

A Case of Accessory Auricles on the Left Preauricular and Left Buccal Areas / 대한피부과학회지

Accessory auricle is a relatively rare congenital anomaly arised from the abnormaI development of the auricular tubercles or from the tissues surrounding the second, third and fourth branchial clefts. Clinically this anomaly is a small akin-colored tag or nodule, soft and globular or cartilaginous consistency on or near the tragus along a line drawn from the tragus to the angle of the mouth or along the anterior margin of the sternomastoid muscle. The lesion is usually solitary and located in the preauricular area but may be multiple and rarely bilateral. We present a typical caae of accessory auricles in 4-day-old female infant. The patient had two skin-colored firm nodules on the left preauricular area and well pedunculated one on the Ieft buccal area near the angle of the rnouth. Histopathologic find.ings showed numerous pilosebaceous units, abundant subcutaneous fat and cartilage tissue in the center of the lesion.

A Case of Sebaceous Carcinoma / 대한피부과학회지

Sebaceous carcinoma of the eyelids is rare and is usually seen in the elderly persons. The meibomian glands of the tarsus are the frequent sites of origin. The characteristic feature is a firm, painless nodule on the upper eyelid, We present a typical case of the sebaceous carcinoma in 60 year-old female. The patient had 1 * 1cm sized, hard, fixed, non-tender mass with bleeding on the right lateral canthus of 3~4 months duration. The histopathology of the lesion showed irregular sized lobules in the dermis with invasive growth to the surrounding stroma. Many fat containing sebaceous celles are seen in the center of the lobules.

A Case of Favre-Racouchot Syndrome / 대한피부과학회지

Favre-Racouchot syndrome(nodular elastosis with cysts and comedones) is a peculiar complication of solar elastosis in which comedones, follicular cysts, and nodules of altered elastic tissue occur mainly sround the orbits, on the cheeks, on snd around the nose, and oceasionally in other exposed areas, but sornetimes on the neck or behind the ears. We present a typical case of the Favre-Racouchot syndrome in a 66 year old man with maxillary cancer. The patient had numerous yellowish cysts and black topped comedones located on the forehead, around the orbits and the nose, on the neck, and also behind the ears of 5 years duration. The histopathology of the lesion showed dilated pilosebaceous openings and epitheliaI lined cysts filled with layered keratin in addition to pronounced solar elastosis.

Emollient Phototherapy of Pityriasis Lichenoides Chronica / 대한피부과학회지

Pityriasis lichenoides Chronica is a cutaneous disorder of unknown etiology and characterized pathologically by vasculitis and clinically by its marked chronicity and lack of specific treatment. Emollient-phototherapy is a recently introduced effective treatment for psoriasis. The authors treated 3 patients with pityriasis lichenoides chronica by the emollient-phototherapy technic with quite satisfactory results.