The Perceptual and Consonant Analysis for the Voice with Hypothyroidism

BACKGROUND AND OBJECTIVES: The main purpose of this study is to clarify perceptual and acoustic analysis for the patients with hypothyroidism after thyroidectomy especially focused on the characteristics of speech articulation with special reference to the consonant production. MATERIALS AND METHODS: The subjects of the research were 40 male and female adults (males : 5, females : 35). They were all received radioactive iodine treatment which after total thyroidectomy. Voice samples were collected during the three stages of after surgery, pre-radioisotope treatment (RIT), and post-RIT. The acoustic analysis was conducted by using Pratt (ver.5.2.21) after measuring voice onset time (VOT). The subjective evaluation of the voices used CAPE-V. RESULTS: A significant decrease in overall severity was displayed in the CAPE-V following RIT. It may be conjectured that this is connected to the change in voice following RIT. The loudness of the sound displayed a significant decrease in the CAPE-V following RIT. It is conjectured that this is connected to the decrease in vocal intensity following RIT. No statistically significant results were revealed for the comparative analysis on the voice onset time (VOT) in all plosives during the three periods. CONCLUSION: Perceptually, the overall severity of the voice with hypothyroidism was changed significantly before and after RIT. Eventhough VOT were not significantly changed, it tended to decrease VOT in patients with hypothyroidism.

Changes of P50 during Hypothermia for Cardiopulmonary Bypass Surgery / 대한마취과학회지

Hemodilution and hypothermia during extracorporeal circulation for open heart surgery affect the oxygen-carrying capacity to the tissue and hemog)obin affinity for oxygen. P50, as an indicator of alteration of hemoglobin affinity, is dependent on the temperature, pH, PCO2 concentration of 2, 3-DPG and type of hemoglobin, and thus it changes with the shift of the oxyhemoglobin dissociation curve to the right or left. We took the blood samples during 3-different stages of cardiopulmonary bypass in 23 patients who underwent open heart surgery; stage I(before chest incision), stage II(during hypothermia), stage III(after chest closure) and measured the level of arterial blood gas and the value of P50 The results were as follows: 1) At the uncorrected temperature, the value of the P50 in stage II(24.80+/-2.06 mmHg) showed a significant decrease compared to the stage I(28.23+/-2.56 mmHg) (P<0.05), but this value was almostly in the normal range. 2) At the corrected temperature, the value of the P50 in stage II(18.59+/-1.88mmHg) showed also a significant decrease compared to the stage I(26.71+/-2.92mmHg) (P<0.01), and increased to the normal range after rewarming. 3) At the uncorrected temperature, arterial PO2 in stage II(380.18+/-48.86mmHg) showed a significant increase compared to stage I(237.62+/-29.20mmHg), which suggested that the increase of the PO was resulted from the effect of the increased FiO2 despite lowered body temperature, while PCO was decreased due to lowered body temperature.

Changes of P50 during Hypothermia for Cardiopulmonary Bypass Surgery / 대한마취과학회지

Hemodilution and hypothermia during extracorporeal circulation for open heart surgery affect the oxygen-carrying capacity to the tissue and hemog)obin affinity for oxygen. P50, as an indicator of alteration of hemoglobin affinity, is dependent on the temperature, pH, PCO2 concentration of 2, 3-DPG and type of hemoglobin, and thus it changes with the shift of the oxyhemoglobin dissociation curve to the right or left. We took the blood samples during 3-different stages of cardiopulmonary bypass in 23 patients who underwent open heart surgery; stage I(before chest incision), stage II(during hypothermia), stage III(after chest closure) and measured the level of arterial blood gas and the value of P50 The results were as follows: 1) At the uncorrected temperature, the value of the P50 in stage II(24.80+/-2.06 mmHg) showed a significant decrease compared to the stage I(28.23+/-2.56 mmHg) (P<0.05), but this value was almostly in the normal range. 2) At the corrected temperature, the value of the P50 in stage II(18.59+/-1.88mmHg) showed also a significant decrease compared to the stage I(26.71+/-2.92mmHg) (P<0.01), and increased to the normal range after rewarming. 3) At the uncorrected temperature, arterial PO2 in stage II(380.18+/-48.86mmHg) showed a significant increase compared to stage I(237.62+/-29.20mmHg), which suggested that the increase of the PO was resulted from the effect of the increased FiO2 despite lowered body temperature, while PCO was decreased due to lowered body temperature.