Assuntos
Gastroenterologia , Endoscopia Gastrointestinal , Consenso , Neoplasias Colorretais , Taxa de Sobrevida , Incidência , Filipinas , Pólipos do Colo , AdenomaRESUMO
@#<p style="text-align: justify;"><strong>INTRODUCTION:</strong> Pre-impaired glucose tolerance (pre-IGT) or compensated hyperinsulinemia, is defined as normal glucose, and elevated insulin two hours after a 75-gram oral glucose load. It is characteristic of the early stages of diabetes mellitus (DM), where beta cells compensate for insulin resistance by increasing insulin secretion to maintain normoglycemia. With continuing beta cell failure, insulin secretion eventually fails, leading to the progression to diabetes. Nonalcoholic fatty liver disease (NAFLD), a common feature of insulin resistance, is found in 50-75% and 42-55% of DM and pre-diabetes patients. We determined if <br />NAFLD was present in patients with pre-IGT.<br /><strong>METHOD:</strong> A study on the determination of NAFLD - diagnosed by liver ultrasound in pre-IGT patients at a university hospital.Descriptive statistics, Chi square test of independence, 2x2 Fischer Exact test, Z test of difference in proportion, were used for statistical analysis with a p-value set at 0.05?.IBMSPSS ver 21 was used as software.<br /><strong>RESULTS:</strong>The mean age of 22 patients was 29.95 years, with average BMI of 25.73 kg/m2;77.3% were female. Average lipid panels were within optimal limits; kidney and liver functions were normal. The mean insulin level was 58.36 uIU/mL. NAFLD was identified in eight of the subjects. <br /><strong>CONCLUSION:</strong> Although pre-IGT is a subclinical phase in the diabetes spectrum, 36% already have NAFLD.This prevalence was lower compared to diabetics and pre-diabetics, but higher compared to the general population.There was a noticeable trend of increasing insulin levels with increasing severity of fatty liver.</p>
Assuntos
Humanos , Masculino , Feminino , Idoso , Pessoa de Meia-Idade , Adulto , Intolerância à Glucose , Resistência à Insulina , Hepatopatia Gordurosa não Alcoólica , Hiperinsulinismo , Estado Pré-Diabético , Células Secretoras de Insulina , Insulinas , Glucose , LipídeosRESUMO
INTRODUCTION: Pre-impaired glucose tolerance (pre-IGT) or compensated hyperinsulinemia, is defined as normal glucose, and elevated insulin two hours after a 75-gram oral glucose load. It is characteristic of the early stages of diabetes mellitus (DM), where beta cells compensate for insulin resistance by increasing insulin secretion to maintain normoglycemia. With continuing beta cell failure, insulin secretion eventually fails, leading to the progression to diabetes. Nonalcoholic fatty liver disease (NAFLD), a common feature of insulin resistance, is found in 50-75% and 42-55% of DM and pre-diabetes patients. We determined if NAFLD was present in patients with pre-IGT.METHOD: A study on the determination of NAFLD - diagnosed by liver ultrasound in pre-IGT patients at a university hospital.Descriptive statistics, Chi square test of independence, 2x2 Fischer Exact test, Z test of difference in proportion, were used for statistical analysis with a p-value set at 0.05?.IBMSPSS ver 21 was used as software.RESULTS:The mean age of 22 patients was 29.95 years, with average BMI of 25.73 kg/m2;77.3% were female. Average lipid panels were within optimal limits; kidney and liver functions were normal. The mean insulin level was 58.36 uIU/mL. NAFLD was identified in eight of the subjects. CONCLUSION: Although pre-IGT is a subclinical phase in the diabetes spectrum, 36% already have NAFLD.This prevalence was lower compared to diabetics and pre-diabetics, but higher compared to the general population.There was a noticeable trend of increasing insulin levels with increasing severity of fatty liver.