Synthesis and antimicrobial activity of novel 3-Chloro- [1- (3,6-(Diphenyl) [1,2,4] Triazolo [3,4b] [1,3,4] Thiadiazole)] -4-(3,4-Diethoxy Phenyl- Azetidin-2-One and their derivatives.

A series of eight novel 2-Azetidinones (8a-h) have been synthesized by cyclocondensation of various Schiff bases based of ATT with chloroacetyl chloride in presences of triethylamine. Various Schiff bases were synthesized by condensation of ATT with various aryl aldehydes (7a-h). The synthesized compounds 8a-h were screened for their antibacterial activity against four microorganisms: Staphylococcus aureus (Gram positive), Bacillus subtilis (Gram positive), Psuedomonas aeruginosa (Gram negative) and Escherichia coli (Gram negative). They were found to exhibit good to moderate antibacterial activity. The structures were confirmed by elemental analysis, IR, 1H-and 13C-NMR spectral data.