RESUMO
PURPOSE: Vascular endothelial growth factor (VEGF) is regarded as a potent mediator of angiogenesis, vascular permeability and tumor cell growth in renal cell carcinoma. This study was designed to evaluate the expression of VEGF, microvessel count (MVC) and to determine their prediction efficacies for prognosis in conventional renal cell carcinomas. MATERIALS AND METHODS: Using immunohistochemistry, the relationship between the expression of VEGF and MVC were evaluated in 60 patients with conventional renal cell carcinomas who underwent a radical nephrectomy at our hospital from 1990 to 2000. Microvessels were identified by immunostaining of endothelial cells for CD-31 antigen. The Kaplan-Meier method and log rank tests were used for univariate analysis, and Cox regression was also used for multivariate analysis. RESULTS: VEGF was expressed on the tumor cell cytoplasm. Of 60 tumors, 23 (38.3%) were weak to strong positive for VEGF. VEGF positivity correlated with microvessel count. Mean MVCs were significantly higher in VEGF-positive tumors (19.5+/-10.4) than in VEGF-negative tumors (11.2+/-7.5). Expression of VEGF was significant correlated to stage, and MVC. The five-year survival rate was 47.2%, in VEGF positive patients, and 81.9% in VEGF negative patients (log rank p=0.02). The five-year survival rate according to MVC, the low microvessel density group (=10/HPF) was 53.9% (log rank p=0.004). Multivariate analysis showed that expression of VEGF (hazard ratio=0.3, p=0.03) and MVD (hazard ratio=0.15, p=0.01) have a prognostic predictive value. CONCLUSIONS: These results suggest that expression of VEGF and MVC may be appreciated as a prognostic factor in conventional renal cell carcinoma.
Assuntos
Humanos , Permeabilidade Capilar , Carcinoma de Células Renais , Citoplasma , Células Endoteliais , Imuno-Histoquímica , Microvasos , Análise Multivariada , Nefrectomia , Prognóstico , Taxa de Sobrevida , Fator A de Crescimento do Endotélio VascularRESUMO
Paratesticular rhabdomyosarcoma is a rare tumor arising from the mesenchymal tissues of the spermatic cord, epididymis, testis, and testicular tunics, and represents 7% of all rhabdomyosarcomas. This tumor occurs predominantly in children and adolescent, but rarely in adult. We report a case of a paratesticular embryonal rhabdomyosarcoma occurring in a 27-year-old man.