RESUMO
Aim To study effects of grape seed proanthocyanidin (GSP) on learning and memory in mice. Methods After po GSP 10,20,40 mg?kg -1 respectively and contemporaneously sc D-galactose 1.25 g?kg -1 for 6 weeks, step down test and Y-type electric maze were used to examine the efficacy of GSE on learning and memory of mice first. Then lipoperoxide(LPO) level in blood and brain of these mice was measured. After po GSP 10,20,40 mg?kg -1 respectively for 2 weeks, the ability of learning and memory was measured by Morris Water Maze task. Results GSP significantly prolonged step-down latency in the mice and decreased number of errors in 5 minutes in step down test; and significantly decreased number of errors of these mice in Y-type electric maze test. LPO level in blood and brain of these mice was lower than that of model group. GSP also increased crossing platform times(CPT) and crossing platform percentages(CPP) in normal mice rested for 30 days in morris water maze test. Conclusion GSP can elevate the ability of learning and memory in mice treated with D-galactose, also improve memory retrieval at the spatial probe trials in normal mice. Mechanisms of these actions may probably be attributable antioxidative activity of GSP.