Drug-induced Hyperprolactinemia Results in Atypical Atypical Fracture / 대한고관절학회지

We report a case of bilateral femur fracture which may have resulted in part from long-term administration of antipsychotic agents. A 43-year-old female patient with pain in both thighs visited our clinic. We conducted Xray and magnetic resonance imaging (MRI) examinations which revealed bilateral femur fractures. The right proximal femur had a complete fracture, and the left proximal femur had an incomplete fracture, both of which were in the subtrochanteric area. The patient was treated by intramedullary nailing in the right femur. Laboratory analysis showed hyperprolactinemia and hypogonadism. Bone mineral density analysis showed osteoporosis. Antipsychotic drug-induced hyperprolactinemia is a well-known phenomenon. Despite concerns about hyperprolactinemia induced osteoporotic fracture in patients treated with only prolactin-elevating medications, the issue has not been extensively studied. If hyperprolactinemia patients suffer from uncontrolled pain, we recommend MRI examination as surgeons should be aware of the possibility of osteoporotic fracture induced by hyperprolactinemia.

Hong Seok-hoo's Translation of "New Edition of Physiology Textbook"(1906) and its Meanings / 의사학

Hong Seok-hoo, who took charge of Jejungwon, was successful in translating Jiro Tsuboi's book titled "Sinpyeonsaengnigyogwaseo (1897)" and publishing it with a title of "New Edition of Physiology Textbook" in 1906. Jiro Tsuboi, the original author of that book, was a doctor having majored in Hygienics in Germany and was also known to have done pioneering work in Hygienics and Occupational and Environmental Medicine in Japan. At that time, he wrote that book for the purpose of teaching his students at Ordinary Middle School and Normal School. Therefore, it was not intended as a Physiology textbook for medical students, but an introductory book explaining Physiology with a wide range of subjects including hygienic matters in a broader sense. Hong Seok-hoo made an almost complete translation of the "New Edition of Physiology Textbook." While editing the book, however, he changed some of the most Japanese-style contents to meet the Korean conditions then, and made up for some insufficient contents with reference to the original author's other books. Although it was not included in an original version of that book, he also compiled a physiology dictionary in order to help Korean readers acquire medical terms in a more systematic way. Just like other textbooks of Jejungwon, the "New Edition of Physiology Textbook" was also put into Korean only. Hong Seok-hoo accepted Japanese-style medical terms, but also changed some of them or coined new words, considering the Korean circumstances then. He seemed to do so in an effort to introduce Western medicine in a more independent way while overcoming his limitations of translation. In particular, this book criticized that a long-term use of cosmetics might cause a serious lead poisoning from a Christian viewpoint, saying that a God-created human body should be kept intact as it is. In addition, in the course of reediting premodern books, the term "Lord" was changed into "God," which is considered a kind of fusion between traditional values and missionary medicine. While translating books, Jejungwon could put such fusion into practice because it was a hospital established under the banner of the propagation of Christianity. Besides the "New Edition of Physiology Textbook," at least five physiology textbooks were also translated into Korean in the last years of Daehan Empire for the purpose of teaching students modern subjects like Physiology, Health and Hygienics in educational institutions including Boseong School, Hwimun School and Soongsil School. On the other hand, the "New Edition of Physiology Textbook" was first translated at the end of Daehan Empire in order to foster more professional doctors in medical schools compared to those schools. In this respect, by translating the "New Edition of Physiology Textbook," Jejungwon can be considered as playing a pioneering role in translating Physiology textbooks in the late Daehan Empire.

The First Textbook of Anatomy in Korea / 대한해부학회지

The first hospital to practice western medicine in Korea, Chejungwon, was opened on April 10, 1885. Then on March 29, 1886, Chejungwon Medical School, Korea's first school to teach western medicine, opened. While anatomy was taught at that time by missionary doctors, there was no Korean translation of an Anatomy textbook. Therefore, Dr. O.R. Avison, who reopened and took charge of Chejungwon Medical School on November 1, 1893, began translating the popular "Gray's Anatomy" with the aid of Korean assistants. Although the text was translated twice, it was not published due one of the manuscripts having gone missing and the other having been lost in a fire. It wasn't until 1906 when the first "Textbook of Anatomy" was translated and published in 3 volumes by Dr. Avison and Mr. Pil Soon Kim (the first graduate of Chejungwon Medical School in 1908). This translation was not based on Gray's Anatomy, but rather on Imada Tsukane's "Practical Anatomy", which had been written in Japanese. During a previous translation, Dr. Avison and Mr. Kim referred to many Chinese and Japanese textbooks, especially for choosing the proper medical terms expressed in Chinese characters. With a basic understanding of how medical terms were expressed in Chinese characters, they decided to translate Imada's textbook. The translation was completed within several months. When comparing the translated textbook with Imada's original one, several pictures were deleted or replaced with others by the translators. Also, much of the narrative was reinforced in detail and new subtitles were used throughout the text. By modifying its contents, they evidently wanted to make this new translation more complete than Imada's original. The text was republished in 1909, but could not be maintained or updated in successive editions due to the Japanese annexation of Korea in 1910.

Primary Cutaneous Cryptococcosis Successfully Treated With Fluconazole

We report a case of primary cutaneous cryptococcosis on Rt. forehead and perioral area of 57 year old woman with non-insulin dependent diabetes mellitus and Lt. cerebral infarction. She had large ulcers with yellowish purulent exudates on Rt. forehead and perioral area for 2months. A histopathological examination from the lesion showed numerous encapsulated, round spores and the organisms were identified as Cryptococcus neoformans in a series of fun-gal studies. The patient received a 5-week course of IV and oral fluconazole with resolution of her skin lesion. The patient is free of any lesion several months after completing therapy. This experience supports the use of fluconazole as initial and single therapy in primary cutaneous cryptococcosis.

A Case of Linear Multiple Cutaneous Leiomyoma / 대한피부과학회지

We report a case of linear arranged multiple cutaneous leiomyoma in a 45-year-old man. About 20 years ago, multiple normal skin colored firm papules developed on the left anterior chest and increased in number and size arranging in linear pattern. Some larger nodular lesions changed into brown in color and became painful after cold exposure. The lesions looked like keloid at first sight but the histopathologic finding showed typical leiomyoma in which the interlacing bundles of smooth muscle fibers with varying amount of collagen bundles intermingled.

A Case of Solitary Glomangioma Occurring on the Right Shoulder / 대한피부과학회지

A 63-year-old man was presented with a tender, solitary nodule on the right shoulder. A biopsy specimen showed various sized irregular vascular lumens in the upper dermis. The vascular walls consisted of an endothelial cell layer and rim of one to three layers of glomus cell nests outside the endothelial cells. The cell nests consisted of round shaped epitheloid cells with relatively uniform round or oval shaped nuclei and pale cytoplasm. These tumor cells were strongly positive for vimentin, and alpha-smooth muscle actin. We report a case of a solitary glomus tumor(glomangioma) that showed the histological features of the multiple type of glomus tumor.

A Case of Familial Benign Chronic Pemphigus Treated With Carbon Dioxide Laser Vaporization / 대한피부과학회지

Familial benign pemphigus is a skin disease with recurrent blistering lesions, mainly in the neck and intertriginous areas. The course of the disease is characterized by spontaneous exacerbations and remissions. The many remedies for this disorder include topical and systemic glucocorticosteroids, and antibacterial and antimycotic agents. However, these therapies usually do not prolong the remission periods. Surgical treatments, such as skin graft, have been more successful. Laser treatment has reported to be effective in recurrent familial benign chronic phemphigus. Here we report a case of familial benign chronic phemphigus that was treated with carbin dioxide laser.

A Case of Familial Benign Chronic Pemphigus Treated With Carbon Dioxide Laser Vaporization / 대한피부과학회지

Familial benign pemphigus is a skin disease with recurrent blistering lesions, mainly in the neck and intertriginous areas. The course of the disease is characterized by spontaneous exacerbations and remissions. The many remedies for this disorder include topical and systemic glucocorticosteroids, and antibacterial and antimycotic agents. However, these therapies usually do not prolong the remission periods. Surgical treatments, such as skin graft, have been more successful. Laser treatment has reported to be effective in recurrent familial benign chronic phemphigus. Here we report a case of familial benign chronic phemphigus that was treated with carbin dioxide laser.

A Case of Classic Kaposi's Sarcoma Showing Good Response to Radiotherapy / 대한피부과학회지

Kaposi's sarcoma is a neoplasm of multifocal origin which manifests primarily as vascular nodules in the skin and other organs. We report a case of classic Kaposi's sarcoma in a 79-year-old man who had asymptomatic dark-brown macules, papules and nodules on his Rt. lower extremities. The biopsy specimen showed typical histopathologic features of Kaposi's sarcoma including dilated, bizarre-shaped vessels, endothelial cell proliferation, and spindle cell formation with vascular slits throughout the dermis. Many of the spindle-shaped cells associated with the proliferating vessels in Kaposi's sarcoma lesion expressed factor VIII-related antigen. Initially he was treated with 4,000 rads of radiation(200 rad per day for 20 successive days), and after two months 2,500 rads of radiation(500 rad per day for 5 successive days). Three months after radiotherapy, skin lesions were healed leaving hyperpigmentation.