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Chinese Journal of Surgery ; (12): 940-943, 2004.
Artigo em Chinês | WPRIM | ID: wpr-360952

RESUMO

<p><b>OBJECTIVE</b>To summarize the initial experience of simultaneous pancreas kidney transplantation (SPK) with portal venous and enteric drainage.</p><p><b>METHODS</b>Between Jane 2001 and Jane 2003, SPK were performed in 5 patients. Systemic venous-enteric drainage (SED) was used in the first 2 patients and portal venous-enteric drainage (PED) in the last 3 cases. All patient were immunosuppressed with quadruple therapy, which included anti-CD25 mAb (Zenapax/Simulect) induction therapy, FK506, mycophenolate mofetil (MMF), and prednisone baseline therapy. The complications were analyzed.</p><p><b>RESULTS</b>Serum glucose and renal function of the 5 cases were normal and no further insulin was needed within 7 days post-operation. No technique complications such as duodenal fistula and thrombosis were observed, One episode of acute rejection of kidney allograft occurred in one patient with SED, and resolved with a bolus corticosteroids. One case with SED and one with PED were died of sepsis and FK506 toxicity 4 weeks after transplantation. The death occurred with functioning pancreas graft. No latter complications were observed in the 3 survived patients with excellent graft functions.</p><p><b>CONCLUSIONS</b>Both methods of SED and PED can be performed successfully and with no latter complications. But with its potential physiologic and immunologic advantages, PED might be a standard procedure for SPK.</p>


Assuntos
Adulto , Feminino , Humanos , Masculino , Diabetes Mellitus Tipo 1 , Cirurgia Geral , Nefropatias Diabéticas , Cirurgia Geral , Drenagem , Métodos , Seguimentos , Intestinos , Cirurgia Geral , Transplante de Rim , Métodos , Transplante de Pâncreas , Métodos , Veia Porta , Cirurgia Geral , Transplante Homólogo , Resultado do Tratamento , Uremia , Cirurgia Geral
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