A Case of Acute Fibrin Pupillary Block Diagnosed by Ultrasonic Biomicroscopy

PURPOSE: To report a case of fibrin pupillary block diagnosed by ultrasonic biomicroscopy (UBM) and treated by argon-neodymium:YAG (Nd:YAG) laser in a patient with uveitis. CASE SUMMARY: A 56-year-old man visited the hospital for decreasing visual acuity and a sudden onset of pain in the right eye. Best corrected visual acuity was 0.02 in the right eye and 1.0 in the left eye. Intraocular pressure (IOP) was 48 mm Hg in the right eye and 18 mm Hg in the left eye. Slit-lamp examination revealed diffuse corneal stromal edema with Descemet's folds and uniform shallowing of the anterior chamber, with 360 degrees of peripheral iridocorneal touch in the right eye. A fibrin membrane was present across the pupil. UBM showed a fibrin membrane across the pupil, uniform shallowing of the anterior chamber, and peripheral angle closure. The lens was displaced posteriorly. A sequential Nd:YAG laser membranectomy was performed that same day, with immediate deepening of the anterior chamber and normalization of the IOP. CONCLUSIONS: UBM can play an invaluable role in the diagnosis of fibrin pupillary block by showing the presence of a fibrin pupillary membrane, accumulation of aqueous in the posterior chamber, and a clear separation between the iris and the lens. Nd:YAG laser membranectomy can be performed effectively in a fibrin pupillary block.

Comparison Between Retinal Nerve Fiber Layer Change and Visual Field Change in Normal Tension Glaucoma

PURPOSE: To evaluate longitudinal changes in retinal nerve fiber layer thickness (RNFL) and visual field in patients with normal tension glaucoma (NTG). METHODS: Thirty eyes of 30 NTG patients and 30 eyes of 30 normal control subjects were enrolled in the present study. RNFL thickness was measured using optical coherence tomography (OCT), and visual field tests were performed using a Humphrey visual field analyzer at baseline and 23.3 +/- 15.3 months later. Changes in RNFL thickness at each clock-hour segment and visual field sensitivities were analyzed. The rates of change in RNFL thickness were also calculated. RESULTS: Significant differences in RNFL thickness were observed between NTG patients and normal control subjects at the 5, 6, 7 and 12 o'clock positions at baseline (p < 0.001). At follow-up, the RNFL thickness change was not significant for normal control subjects, although it was significant for NTG patients at the 4, 5, 6, 7, 11 and 12 o'clock positions (p < 0.001). Visual field parameters did not change significantly in the normal control subjects or NTG patients. The reduction rates of RNFL thickness were 0.38 microm/month for the NTG patients and 0.11 microm/month for the normal control group, displaying a 3.5-fold faster reduction rate for NTG patients. CONCLUSIONS: The NTG group showed greater reductions in RNFL thickness in the upper and lower sectors over time; however, the visual field parameters did not change significantly. The results suggest that progression of glaucoma can be detected in an earlier stage using OCT than can be detected using a visual field test.

The Changes in the Area of the Anterior Capsulotomy Size

PURPOSE: To investigate whether there was any difference in anterior capsular opening area between the use of silicone intraocular lens(IOL) and acrylic IOL after continuous curvilinear capsulorhexis(CCC). METHODS: In 42 eyes, acrylic IOL(Acrysof(R), Alcon, U.S.A.) were inserted into the capsular bag during phacoemulsification, and in 36 eyes silicone IOL(Chiroflex II(R) , Chiron, U.S.A.) were inserted. The reduction rate of anterior capsular opening area at first, second, third and sixth postoperative month were compared between the two groups. RESULTS: On the whole, the reduction in anterior capsular opening area was larger by 0.574 mm 2 when silicone IOL was used, but the different was not statistically significant(P= .061). The result was the same at 1 month(P= .149), 2 months(P= .144), 3 months(P= .223), 6 months(P= .163) after surgery. CONCLUSIONS: We concluded that there was little difference in the changes of anterior capsular opening area after CCC between the use of silicone IOL and acylic IOL, and other factors should be considered.

Two Cases of Photic Retinopathy by Excessive Exposure to Light of Sun and Operating Microscope

PURPOSE: To report two cases of photic retinopathy induced by excessive exposure to sunlight and operation microscope during cataract surgery. METHODS: Two cases of photic retinopathy(case 1: a 33 year old woman exposed to excessive sun light, case 2: a 66 year old woman exposed to direct operating microscope during cataract surgery) were followed and observed with visual acuity, fundus examination and fluorescein angiography without specific treatment. RESULTS: In both cases, best corrected visual acuity was improved to 1.0 and central scotoma decreased significantly.

A Study on UVI - induced DNA Synthesis in Mouse Skin in Vivo Studied by Autoradiography / 대한피부과학회지

The status of DNA synthesis and the effect of UV radiation on the DNA synthesis were studied in mouse skin by microautoradiography. Mice exposed to 100mJ/cm of UVB were injected intradermally with tritiated thymidine, 5 minutes, 2, 6 and 24 hours after irradiation and biopsies were processed for light microscopic autoradiography, A total of 25 ICR female albino haired mice were used as subjects. We compared heavily labeled cells(>10 grains/nucleus) and sparsely labeled cells (3-10 grains/nucleus) in UVL irradiated skin with nonirradiated control skin. 1. Within 5 minutes after UVL exposure an apparent depression in the number of heavily labeled cells occurred. This reduction was statistically significant and remained so for at least six hours post,irradiation. By 24 hours after UVL exposure, the reduction was recovered to nearly control level. 2. By five minutes after UVL exposure, sparsely labeled cells were observed in basal cell layer and differentiated cell layer. The nurriber of sparsely labeled cells appeared highest at five minutes after UVL exposure and then tended to fall to nearly control level at 24 hours. This aberrant type of TdR H incorporation is thought to represent unscheduled DNA synthesis to repair pyrimidine dimers formed in UVL injured DNA molecules,

Effects of UV Light on DNA Synthesis Studied by Autoradiography

No abstract available.

Anthralin Therapy for Psoriasis / 대한피부과학회지

Our Study was performed to evaluate the effect of anthralin for the treatment of psoriasis. Thirty seven patients with mild form of psoriasis were trested with topical anthralin ointment. 1. Twenty patients(54%) showed clearing of lesion within 8 weeks. 2. Treatment with anthalin was failed in 15 patients(40.5%). 3. Side reaction such as staining, pruritus and erythems was noted in 18 patients (48.6%), among them, 8 patients(21.6%) terminated the therapy with anthralin due to marked side reaction.

A Clinical Investigation of Pustulosis Palmaris et Plantaris / 대한피부과학회지

A clinical investigation of the patients with pustulosis palmaris et plantaris (PPP) was made on 36 patients who were seen at the Department of Dermatology, Seoul National University Hospital, from January 1986 through June 1987. The results were summarized as follows : 1. In this series of 36 patients, 14 patients(38.9%) were male and 22 patients (61.1%) were female. Females are more subject to the affection than males. 2. The mean age of onset in male was 30.6 years and in female it was 38.4 years, indicating a earlier onset in male. The peak age of incidence in male was between 20 and 29 years and in female, between 40 and 49 years. 3. The sites of involvement were mostly bilateral hands and feet. 4. the season of the year did not influence the severity of the skin lesions in 68.9%. 5. Nine patients(28.1%) had psoriasis-like skin lesions and 14 patients(43.1%) had nail changes out of 32 patients with PPP. 6. No direct relationship could be found between pustular eruptions and focal infections, such as tonsilitis, otitis, dental abscess and sinusitis. 7. Remmission of the pustular eruptions could be achieved in 5 out of 10 patients treated with etretinate and in 4 out of 11 patients treated with ketoconazole for more than 4 weeks' treatment

A Case of Dermatomyositis Associted with Maxillary Carcinoma / 대한피부과학회지

A 30-year old female had proximal muscle weakness, periungal telangiectasia and purplish red erythema and edema on the face. Diagnosis of dermatomyositis was estabiiished by clinical manifestations, muscle enzyme study, electromyogram, histologic findings of skin and muscle. She was treated with systemic steroid with some improvemellt. About 1 year after the onset of dermatomyositis, aggravated skin lesion and exophthalmos were noted on right eyelid. Orbit computerized tomography scan showed maxillary carcinoma. She treated with systemic steroid, 5-fluorouracil and cis-platin with partial remission and some improvement of dermatomyositis.