Helicobacter pylori infection and iron deficiency in non-elderly adults participating in a health check-up program

Background/Aims@#Helicobacter pylori infection is presumably associated with iron deficiency and iron deficiency anemia (IDA). This study aimed to evaluate the relationship between H. pylori infection and the decline in iron stores in non-elderly adults during their health check-ups. @*Methods@#We identified a total of 1,069 subjects who were tested for iron, ferritin, and total iron-binding capacity during their health check-ups, from January 2016 to May 2017. Of these, subjects who underwent endoscopy via rapid urease test and those aged 65 years or below were finally enrolled. @*Results@#Overall, 281 subjects were enrolled, and 187 patients (66.5%) tested positive for H. pylori. The mean age was 36.1 years (range, 22 to 65), and 176 subjects (62.6%) were male. The mean levels of hemoglobin (14.1 ± 1.7 g/dL vs. 14.6 ± 1.4 g/dL, p = 0.019) and ferritin (121.7 ± 106.9 ng/mL vs. 151.8 ± 107.8 ng/mL, p = 0.027) in the H. pylori-positive group were significantly lower than those in the H. pylori-negative group. Iron deficiency (ferritin < 30 ng/mL) was more common in patients with H. pylori infection (p = 0.002). There was no significant difference in anemia (hemoglobin < 13 g/dL in men, < 12 g/dL in women) or IDA (anemia, ferritin < 10 ng/mL, and transferrin saturation < 16%) with H. pylori. Logistic regression analysis demonstrated that female sex (odds ratio, 197.559; 95% confidence interval, 26.461 to 1,475.015) and H. pylori infection (odds ratio, 3.033; 95% confidence interval, 1.216 to 7.567) were factors associated with iron deficiency. @*Conclusions@#H. pylori infection is associated with iron deficiency, suggesting a decline in iron stores among infected non-elderly adults.

A Case of Unusual Suicide due to Overlapping Inhalation of Nitrous Oxide and Carbon Monoxide / 대한법의학회지

Nitrous oxide (N2O) is a chemical used as a medical anesthetic supplement, industrial semiconductor cleaning agent, and food additive in the manufacture of whipping cream. Nitrous oxide causes hypoxemia and suffocation during repeated inhalation. In severe cases, it causes coma and death. Some of those who are not aware of the dangers still illegally obtain and abuse nitrous oxide even with the law enforcing its use, and some people seem to have abused nitrous oxide after purchasing large amounts in small containers before the law has taken effect. Deaths from misuse of nitrous oxide are extremely rare in South Korea compared to those from other addictions such as carbon monoxide poisoning. No autopsy or follow-up blood tests were performed in this case.However, this is a unique and rare case in which carbon monoxide inhalation due to the combustion of lightning coal at the last moment overlaps with continuous inhalation of large amounts of nitrous oxide for several days beyond simple hallucination use, and is included in this report with a simple literature review.

Development of Clinical Guideline for the Diagnosis and Evaluation of Depression: Focused on Diagnosis Guideline / 신경정신의학

OBJECTIVES: The aim of this study is to develop guideline for use in diagnosis of depression. METHODS: Development of this guideline was processed according to the ADAPTE manual, which was developed for adaptation of good clinical practice guidelines. Important key questions were determined, and a systematic review of clinical practice guidelines was performed. The contents of guidelines selected by comparison of the methodological quality and currency were evaluated with regard to the applicability and acceptability. Answers to key questions and clinical recommendations were established by peer review. RESULTS: There has been no evidence on strategies to improve the accuracy and rate of diagnosis of depression. The screening tools for depression were useful in diagnosis of depression in clinical practice. CONCLUSION: The results of this study may suggest the necessity of strategies to improve the validity and reliability of diagnosis of depression. In contrast, scales for screening depression can be useful in diagnosis of depression. This guideline did not include systematic reviews regarding useful scales for diagnosis of depression. In the future, amendment of this guideline might be needed in order to supplement limitations.

Development of Clinical Guideline for the Diagnosis and Evaluation of Depression: Focused on Evaluation Guideline / 신경정신의학

OBJECTIVES: The aim of this study is to develop guideline for evaluation of depression. METHODS: Development of this guideline was processed according to the ADAPTE manual, which was developed for adaptation of good clinical practice guidelines. Important key questions were determined, and a systematic review of clinical practice guidelines was performed. The contents of guidelines selected by comparison of the methodological quality and currency were evaluated with regard to the applicability and acceptability. Answers to key questions and clinical recommendations were established by peer review. RESULTS: Careful evaluations on the characteristics of depression, including subtype, severity, suicidality, and psychiatric and physical comorbidities were recommended because these factors can have an influence on course and prognosis in treatment of depression. CONCLUSION: The results of this study may contribute to the systematic evaluation of depression, based on clinical importance. However, this guideline did not include systematic reviews regarding useful scales for evaluation of depression. In the future, amendment of this guideline might be needed in order to supplement limitations.

Clinical Characteristics of Traumatic Rhegmatogenous Retinal Detachment

PURPOSE: To analyze the clinical characteristics and factors affecting visual outcome after surgery in rhegmatogenous retinal detachment resulting from blunt trauma. METHODS: We retrospectively reviewed the medical records of 122 patients (122 eyes) who were diagnosed with rhegmatogenous retinal detachment after blunt trauma and who had been under regular observation for at least six months. RESULTS: The frequency of traumatic rhegmatogenous retinal detachment was 122 eyes out of 989 total eyes with rhegmatogenous retinal detachment (12.3%). The mean age was 36.3 years (7-66): 93 (76.2%) male, 29 (23.8%) female. The most common type of retinal break was a horseshoe-shaped retinal tear (31.1%), and the most common location was the superotemporal quadrant (32.8%) and on the retinal equator or anterior to the equator (90.2%). Patients older than 50 years had a shorter latent period from the traumatic event to the symptom presentation (p=0.028). Whether the retinal detachment involve the macula, the extent of detachment, the initial visual acuity and the time interval from symptom presentation to treatment influenced on the postoperative visual recovery. CONCLUSIONS: Traumatic rhegmatogenous retinal detachment had a favorable visual recovery in cases of early diagnosis. Therefore, detailed and frequent examinations of the retinal periphery after ocular trauma are important if vision is to be preserved. Older patients showed a tendency to advance into traumatic rhegmatogenous retinal detachment more rapidly after trauma than did younger patients. Therefore, elderly patients will require special intensive treatment following traumatic retinal detachment.

Clinical Characteristics of Traumatic Rhegmatogenous Retinal Detachment

PURPOSE: To analyze the clinical characteristics and factors affecting visual outcome after surgery in rhegmatogenous retinal detachment resulting from blunt trauma. METHODS: We retrospectively reviewed the medical records of 122 patients (122 eyes) who were diagnosed with rhegmatogenous retinal detachment after blunt trauma and who had been under regular observation for at least six months. RESULTS: The frequency of traumatic rhegmatogenous retinal detachment was 122 eyes out of 989 total eyes with rhegmatogenous retinal detachment (12.3%). The mean age was 36.3 years (7-66): 93 (76.2%) male, 29 (23.8%) female. The most common type of retinal break was a horseshoe-shaped retinal tear (31.1%), and the most common location was the superotemporal quadrant (32.8%) and on the retinal equator or anterior to the equator (90.2%). Patients older than 50 years had a shorter latent period from the traumatic event to the symptom presentation (p=0.028). Whether the retinal detachment involve the macula, the extent of detachment, the initial visual acuity and the time interval from symptom presentation to treatment influenced on the postoperative visual recovery. CONCLUSIONS: Traumatic rhegmatogenous retinal detachment had a favorable visual recovery in cases of early diagnosis. Therefore, detailed and frequent examinations of the retinal periphery after ocular trauma are important if vision is to be preserved. Older patients showed a tendency to advance into traumatic rhegmatogenous retinal detachment more rapidly after trauma than did younger patients. Therefore, elderly patients will require special intensive treatment following traumatic retinal detachment.

Gastrointestinal Autostapler(GIA)-Assisted Zenker's Diverticulectomy / 대한이비인후과학회지

Zenker diverticulum is rare and symptoms of diverticulum are atypical. This is most commonly seen at the Killian's triangle. This is caused by altered motility, which results in abnormal intraluminal pressure and the pushing of the mucosa through weakness of the wall. Treatment is surgical via an endoscopic or external approach. Previous external approaches are associated with high com-plication rates and morbidity. We report a new external surgical approach using the gastrointestinal autostapler (GIA) instrument.

Clinical Characteristics in Geriatric Trauma Victims between a Metropolitan City and Rural Areas

PURPOSE: Republic of Korea is now progressing to an aging society. Ones of rural areas in Korea are already aged societies. Others are post-aged societies in some areas. The urban areas in Korea is westernized, industrialized, and so crowded but the rural areas are still traditional and agricultural. The geriatric trauma victims in rural area have been neglected in that the rural medical environment including emergency medical service is not well-equipped and wellorganized. The purpose of this study is to evaluate clinical comparison of geriatric trauma victims between urban and rural area to prevent geriatric trauma and improve geriatric trauma outcomes. METHODS: In urban area, there was 382 geriatric trauma victims. And In rural area, there was 230 geriatric trauma victims. They was enrolled in this study from 1 Jan 2007 to 31 Dec 2007. We analyzed the medical data by using SPSS 12.0 and compared between urban and rural geriatric trauma victims in RTS (Revised trauma score), NISS (New injury severity score), vital sign, mentality, access, transportation, trauma time, mechanism of injury, and disposition. RESULTS: The mean age was 73.33+/-6.71 vs 73.00+/-6.13 (urban area geriatric trauma victims vs rural area geriatric trauma victims). The mean NISS was 7.18+/-8.66 vs 11.10 +/-11.10 (p-value=0.000). The mean RTS was 7.73+/-0.59 vs 7.67+/-0.75 (p-value=0.272). The factor of access, transportation, mechanism of injury, and disposition between urban and rural geriatric trauma victims showed statistical difference by chi-square test. CONCLUSION: In conclusion, rural area geriatric trauma victims were visited the emergency medical center with different method and route compared with the urban area geriatric trauma victims, showed the difference in mechanism of injury and results of medical treatment and thus needs to be concerned about difference of geriatric trauma between urban and rural area for prevention and better medical outcome.

Metastasizing Pleomorphic Adenoma: Report of a Case / 대한이비인후과학회지

Benign metastasizing pleomorphic adenoma is an extremely rare neoplasm, although the pleomorphic adenoma is the most common neoplasm affecting the salivary glands. Metastasis commonly develops many years after the excision of the primary tumor and is usually proceeded by local recurrences. This is a case of pleomorphic adenoma in the parotid gland without a local recurrence. We describe a case of metastasizing pleomorphic adenoma in a 69 year-old woman. The literature concerning the subject is reviewed. The treatment of choice for the metastatic pleomorphic adenoma appears to be complete surgical excision.

Altered Expression of Peritoneal Aquaporin-in Response to Osmotic Stimuli and Glucocorticoid / 대한신장학회잡지

BACKGROUND: To examine the changes of peritoneal aquaporin-1 (AQP-1) expression and peritoneal transport in rats in response to continuous exposure of same osmotic stimuli which was induced by either mannitol or glucose in dialysis solution or glucocorticoids co-reatment. METHODS: Twenty-eight male Sprague-awley rats were divided into three groups:group I (n=10) rats were dialyzed with 5% mannitol solution (0.27 M); group II (n=9) rats were dialyzed with 5% glucose solution (0.28 M): and group III (n=9) rats were dialyzed with 5% glucose solution (0.28 M) accompanied by daily injection of dexamethasone (2 mg/kg, im) for the last 7 days of the 1 month dialysis period. Dialysis exchanges were performed 2 times a day for 1 month with 25 mL per exchange. Immunohistochemistry was performed using a polyclonal anti AQP-1 antibody. The peritoneal membrane (PM) function was assessed by one-hour PET for comparing transport characteristics. PM transport rates were assessed by D/P of urea nitrogen and D/Do of glucose. Water transport of peritoneal membrane was assessed by D/P of sodium at 1 month. RESULTS: The immunolabeling intensity of peritoneal AQP-1 was markedly increased and the most prominent in rats dialyzed with 5% glucose solution accompanied by injection of dexamethasone (group III). Consistent with this, D/P of sodium in rats of group III was significantly decreased (p<0.05), indicating an increased water permeability and ultrafiltration. In contrast, peritoneal AQP-1 labeling intensity was weaker in PD groups dialyzed with mannitol (group I) and glucose (group II) solution having an identical osmolality and was not different between the groups. Rats in group I exhibited significantly lower D/Do of glucose and increased D/P of urea nitrogen, suggesting high PM transport. CONCLUSION: These results indicate that the change of peritoneal AQP-1 expression is not specific to the glucose itself, but rather it could be altered in response to the changes of osmolality per se in PD solution. Moreover, corticosteroid up-egulates peritoneal AQP-expression, which is paralleled by an increased water permeability.

The Suppression of Peritoneal Advanced Glycosylation End Product Formation by Intraperitoneal Aminoguanidine / 대한신장학회잡지

BACKGOUND: The purpose of the study was to evaluate the effect of aminonguanidine on the inhibition of advanced glycosylation end product (AGE) formation and the expression of peritoneal vascular endothelial growth factor (VEGF). Then we analyzed the functional and morphological alterations of peritoneal membrane during long-term PD in rats. METHODS: Male Sprague-Dawley rats were randomly divided into 3 groups:group I (n=6), control rats with PD catheter but not dialyzed; group II (n=9), rats dialyzed with 4.25% glucose solution for all exchanges; group III (n=9), rats dialyzed with 4.25% glucose solution containing aminoguanidine (25 mg/kg) for all changes. Dialysis changes were performed 3 times a day with 25 mL/each exchange for 12 weeks. Immunostaining was performed using a monoclonal anti-AGE antibody and a polyclonal anti-VEGF antibody. One-hour peritoneal equilibration test were performed at every 4-week for the comparison of peritoneal transport characteristics. RESULTS: Expressions of peritoneal AGE and VEGF in dialyzed groups (group IIand III) were higher compared to control group. The level of AGE immunostaining in group III was significantly lower than in the group II. But peritoneal VEGF expression did not differ between the dialyzed groups. In dialyzed groups, D/DO glucose was significantly lower whereas D/P urea was significantly higher than in the control group. On linear regression analysis, peritoneal AGE and VEGF accumulation were directly correlated with D/DO glucose and D/P urea nitrogen. But there was no statistical significance in D/DO glucose and D/P urea nitrogen between the dialyzed groups. CONCLUSION: Peritoneal accumulation of AGE and VEGF increased with time on CAPD in dialyzed groups. Intraperitoneal aminoguanidine was greatly suppressed peritoneal AGE accumulation but no attenuated long-term dialysis related peritoneal hyperpermeability. The VEGF formation may be one of the several mediators resulting the functional deterioration of the peritoneal membrane in long-term peritoneal dialysis.

Altered Expression of Peritoneal Aquaporin-1 and Water Transport during Long-term Peritoneal Dialysis in Rats / 대한신장학회잡지

BACKGROUND: The present work was designed to examine the altered expression of peritoneal AQP-1 and water transport of peritoneal membrane during the long-term peritoneal dialysis with hypertonic glucose solution in rats. METHODS: Eighteen Sprague-Dawley male rats were randomly divided into 2 groups: control rats (n=6) with peritoneal catheter but not dialyzed; rats with peritoneal dialysis (PD) (n=12) were dialyzed with 4.25% glucose dialysate for all exchanges. Before completion of the study, 4 animals in PD group were euthanized owing to nonfunctional catheters or peritonitis, leaving 14 animals for the analysis. Dialysis exchanges were performed 3 times a day with 25 mL/each exchange for 12 weeks. Immunoperoxidase staining was performed using monoclonal anti-AGE antibody and polyclonal anti-AQP-1 antibody. The slides were read by 5 different examiners in a blind fashion. The staining intensity was graded semiquantitively from 0 to 3. The peritoneal membrane function was assessed by performing one-hour peritoneal equilibration tests every 6 week for comparing transport characteristics. Peritoneal membrane transport rate was assessed by D/P of urea nitrogen and D/Do of glucose. Water transport of peritoneal membrane was assessed by D/P of sodium at 12 week. RESULTS: The expression of peritoneal AQP-1 was increased in rats with PD, compared to control rats. Consistent with this, D/P of sodium in rats with PD was significantly decreased compared to control rats (0.58+/-0.04 vs 0.86+/-0.07, p<0.05), indicating high peritoneal water permeability in response to long-term peritoneal dialysis. Moreover, rats with PD were associated with significantly lower D/Do of glucose and higher D/P of urea nitrogen, suggesting high peritoneal membrane transport. CONCLUSION: High expression of peritoneal AQP-1 was associated with an increased peritoneal water permeability in response to long-term peritoneal dialysis with 4.25% glucose for 12 weeks. The underlying mechanisms for the increased AQP-1 expression need to be examined whether it is due to the continuous exposure to the dialysis solution containing high glucose concentration itself or compensatory effects of slowly developed concomitant ultrafiltration failure in chronic peritoneal dialysis.

A Case of Testicular Plasmacytoma Presenting as the First Manifestation of Multiple Myeloma / 대한비뇨기과학회지

No abstract available.

Strangulation of the Penis by Self-circumcision Device: A Case Report / 대한남성과학회지

Penile strangulation developed by wearing metallic or non-metallic objects is unusual but potentially serious. We report a case of 33-year-old man who presented with penile strangulation after applying the device for self-circumcision. The device was removed and after debridement of the infected necrotic tissues and antibiotic therapy, conventional circumcision was performed. It is stressed that circumcision should be performed by urologists.